On-demand drug delivery from temperature-responsive polyurethane membrane

Chen, Yi; Wang, Rui; Zhou, Jian; Fan, Haojun; Shi, Bi

doi:10.1016/j.reactfunctpolym.2011.01.010

Cited by 38 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is widely known that PEG segment had an excellent hydrophilicity and was more ready to get an access to the incubation media, which might account for its superiority in degradability. Nevertheless, it was worthwhile to point out that the melting point of PU [2000] and PU [3000] was around 40°C, just a little bit higher than the normal temperature of the human body at 37°C, which made itself quite possible to facilitate drug‐delivery system as temperature‐sensitive carrier 30…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of biodegradable polyurethanes based on L‐cystine/cysteine and poly(ϵ‐caprolactone)

Wang

Zheng

Wang

et al. 2012

J of Applied Polymer Sci

View full text Add to dashboard Cite

Tunable biodegradable polyurethanes (PUs) with favorable mechanical properties were synthesized from 1,6‐hexamelthylene diisocyanate (HDI) as the hard segment, poly(ϵ‐caprolactone) (PCL) as the soft segment, and L‐cystine ester as chain extender. The structure of PUs was confirmed by FTIR and 1H‐NMR. The results of differential scanning calorimeter, thermogravimetric analysis, dynamic mechanical analysis, and tensile test revealed that the thermal and mechanical properties of PUs were strongly influenced by the molecular weight of soft segment PCL. In the presence of glutathione, the disulfide group cleaved into thiols, realizing the PUs degraded and the molecular weight decreased. For PU [550], it remained only 50% of the original Mw. Evaluation of cell viability demonstrated the nontoxicity of the PUs, which facilitated their potential in biomedical applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of biodegradable polyurethanes based on L‐cystine/cysteine and poly(ϵ‐caprolactone)

Wang

Zheng

Wang

et al. 2012

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Biodegradable elastomeric polyurethane has been used for biomedical applications due to its tunable mechanical properties, processability, biodegradability, and good biocompatibility . It has been processed into films, electrospun fibers, and porous scaffold, for tissue engineering application as well as nano/micro particulates, membranes, and matrices for controlled drug release. The biodegradable polyurethane has also been combined with traditional conductive polymers or organic additives to form PU‐based conductive composites for tissue engineering .…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of conductive, biodegradable, elastomeric polyurethanes for biomedical applications

Yepez

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

Biodegradable conductive polymers are currently of significant interest in tissue repair and regeneration, drug delivery, and bioelectronics. However, biodegradable materials exhibiting both conductive and elastic properties have rarely been reported to date. To that end, an electrically conductive polyurethane (CPU) was synthesized from polycaprolactone diol, hexadiisocyanate, and aniline trimer and subsequently doped with (1S)-(+)-10-camphorsulfonic acid (CSA). All CPU films showed good elasticity within a 30% strain range. The electrical conductivity of the CPU films, as enhanced with increasing amounts of CSA, ranged from 2.7 ± 0.9 × 10(-10) to 4.4 ± 0.6 × 10(-7) S/cm in a dry state and 4.2 ± 0.5 × 10(-8) to 7.3 ± 1.5 × 10(-5) S/cm in a wet state. The redox peaks of a CPU1.5 film (molar ratio CSA:aniline trimer = 1.5:1) in the cyclic voltammogram confirmed the desired good electroactivity. The doped CPU film exhibited good electrical stability (87% of initial conductivity after 150 hours charge) as measured in a cell culture medium. The degradation rates of CPU films increased with increasing CSA content in both phosphate-buffered solution (PBS) and lipase/PBS solutions. After 7 days of enzymatic degradation, the conductivity of all CSA-doped CPU films had decreased to that of the undoped CPU film. Mouse 3T3 fibroblasts proliferated and spread on all CPU films. This developed biodegradable CPU with good elasticity, electrical stability, and biocompatibility may find potential applications in tissue engineering, smart drug release, and electronics. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2305-2314, 2016.

show abstract

“…Also, the ability to produce BioPUs as foams or elastomers grants additional degrees of freedom in the design of products with desired properties [178]. Drug delivery systems based on BioPUs can be in the form of nano-or microparticulate systems [179] such as micelles [180][181][182] nanoparticles [183,184], nanocapsules [185][186][187], microspheres [188,189] and pellets [190], as well as membrane systems [191][192][193][194][195].…”

Section: Biopu-based Drug Delivery Systemsmentioning

confidence: 99%