On Diabetic Acidosis

Atchley, Dana W.; Loeb, Robert F.; Richards, Dickinson W.; Benedict, Ethel M.; Driscoll, Mary E.

doi:10.1172/jci100504

Cited by 372 publications

(52 citation statements)

References 10 publications

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“…This does not, of course, imply that there is no intrinsic tubular mechanism for sodium transport which may be influenced by the character and flow of tubular urine, as has been pointed out (22,24). However, such observations as the failure of a sulfate diuresis to sweep out sodium chloride (25,26), the variable response to urea loads (1,2,6,23), and the cutback in sodium excretion in some diabetic patients despite continued massive glycosuria (18,27,28), suggest that the osmotic influence of the injected solute within the renal tubule may be only one of several determinants. This view is, on the whole, consonant with that expressed in greater detail by Wolf (29).…”

Section: Methodsmentioning

confidence: 98%

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

Tarail¹,

Seldin²,

Goodyear³

1951

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 98%

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

Tarail¹,

Seldin²,

Goodyear³

1951

J. Clin. Invest.

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“…Several studies have provided evidence that insulin decreases urinary sodium excretion (1)(2)(3)(4)(5). Withdrawal ofinsulin in humans with diabetes mellitus results in a diuresis and natriuresis that may not be due solely to the observed glucosuria and ketonuria.…”

Section: Introductionmentioning

confidence: 99%

Insulin stimulates volume absorption in the rabbit proximal convoluted tubule.

Baum¹

1987

J. Clin. Invest.

225

128

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The present in vitro microperfusion study examined whether insulin affects volume absorption (J.) in the proximal convoluted tubule (PCT). PCT were perfused with an ultrafiltrate-like solution and were bathed in a serum-like albumin solution. Addition of a physiologic concentration of 10-10 M insulin to the bathing solution resulted in a stimulation of J. and a more negative transepithelial potential difference (PD). There was a progressive stimulation of the lumen negative PD and J, with higher insulin concentrations. Maximal stimulation occurred at 10-" M bath insulin. The insulin-induced stimulation of volume reabsorption was also observed when glucose and amino acids were removed from the luminal perfusate. Direct examination of the effect of insulin on glucose, chloride, and bicarbonate absorption demonstrated that the transport of all these solutes was stimulated by insulin. Addition of insulin to the luminal perfusate had no affect on J,. These data show that insulin has a direct effect to stimulate J. in the proximal tubule.

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“…Early studies by Atchley et al. demonstrate that discontinuation of an insulin infusion to diabetic patients results in a brisk natriuresis 30. Miller and Bogdonoff show that infusion of insulin into normal subjects results in a reduction in urinary sodium excretion 31.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of D ₄ Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

Zhang

Ren

et al. 2016

JAHA

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BackgroundIon transport in the renal proximal tubule (RPT), which is increased in essential hypertension, is regulated by numerous hormones and humoral factors, including insulin and dopamine. Activation of dopamine receptor inhibits sodium reabsorption, whereas activation of insulin receptor increases sodium reabsorption in RPTs, and hyperinsulinemic animals and patients have defective renal dopaminergic system. We presume that there is an inhibition of D4 receptor on insulin receptor expression and effect, and the regulation is lost in spontaneously hypertensive rats (SHRs).Methods and ResultsInsulin receptor expression was determined by immunoblotting, and Na+‐K+‐ATPase activity was detected in both Wistar‐Kyoto (WKY) and SHR RPT cells. Stimulation of D4 receptor with PD168077 decreased expression of insulin receptors, which was blocked in the presence of the calcium‐channel blocker, nicardipine (10−6 mol/L per 24 hours), in cell culture medium without calcium or in the presence of inositol 1,4,5‐trisphosphate (IP3) receptor blocker (2‐aminoethyl diphenylborinate [2‐ADB]; 10−6 mol/L per 24 hours), indicating that extracellular calcium entry and calcium release from the endoplasmic reticulum were involved in the signal pathway. Stimulation of the insulin receptor stimulated Na+‐K+‐ATPase activity, whereas pretreatment with PD168077 for 24 hours decreased the inhibitory effects of insulin receptor on Na+‐K+‐ATPase activity in WKY cells. However, in SHR cells, inhibition of D4 receptor on insulin receptor expression and effect were lost.ConclusionsActivation of D4 receptor inhibits insulin receptor expression in RPT cells from WKY rats. The aberrant inhibition of D4 receptor on insulin receptor expression and effect might be involved in the pathogenesis of essential hypertension.

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On Diabetic Acidosis

Cited by 372 publications

References 10 publications

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

Insulin stimulates volume absorption in the rabbit proximal convoluted tubule.

Inhibition of D ₄ Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

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On Diabetic Acidosis

Cited by 372 publications

References 10 publications

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

Insulin stimulates volume absorption in the rabbit proximal convoluted tubule.

Inhibition of D 4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

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Inhibition of D ₄ Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells