On differences between some effects of salicylate and 2 : 4-dinitrophenol

Waltner, K; M, Csernovszky; Kelemen, E.

doi:10.1016/0006-2952(59)90056-5

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…However, it is possible that this effect on lysosomes is part of a more general phenomen' on involving all membranes and that it may not have any practical significance on the activity of salicylic acid. Salicylate in vivo increases the uptake of water by erythro cytes [12]. We have also shown that 0.01 m salicylate increases the suscep tibility of red blood cells to osmotic lysis.…”

Section: Discussionmentioning

confidence: 68%

Effect of Bases and Accelerants on the Anti-Inflammatory Activity of Topical Corticosteroids

Sárkány¹,

Gaylarde²

1976

Dermatology

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The use of measurement of skin thickness in guinea pigs has been compared with other techniques for assessment of topical applications. This method has provided us with an accurate evaluation of the corticosteroid dose-response curve and the effect of bases. The method has shown that non-steroid prostaglandin synthesis inhibitors can also be demonstrated to possess topical anti-inflammatory activity. As expected, indomethacin acts synergistically when formulated with hydrocortisone. Contrary to our expectation, both salicylic acid and acetylsalicylic acid show antagonism with hydrocortisone. This finding may be of clinical significance. We have also found that a combination of salicylic acid and indomethacin produces striking inflammatory changes in guinea pig skin which points to interaction of these two drugs in the guinea pig. The relevance of this phenomenon to both the mode of action of the two drugs and their use in clinical practice remains to be elucidated, but preliminary tests suggest that similar changes take place in human skin.

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Section: Discussionmentioning

confidence: 68%