On dihydropyridines. XXIV. Partial hydrogenation of some 3,5-dicyanopyridines

Kuthan, J.; Musil, L.; Kohoutová, Anna

doi:10.1135/cccc19713992

Cited by 3 publications

(1 citation statement)

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“…The combined organic layers were dried (Na 2 SO 4 ) and evaporated under reduced pressure to give a yellow solid that was purified on silica gel column chromatography (EtOAc-CHCl 3 , 6:4 v/v) to afford pure 10a (0.51 g, 3.6 mmol, 73%); mp 80-82°C (Lit. 5…”

Section: 6-dibromo-4-methylpyridine-35-dicarbonitrile (9a)mentioning

confidence: 99%

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

Rienzo¹,

Mellini²,

Tortorella³

et al. 2010

Synthesis

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Nicotinamide plays a key role in many biological processes and, as a consequence, its derivatives could be attractive for the synthesis of biologically active compounds. Here a rapid and efficient way of preparing alkyl derivatives of nicotinamide, precisely, 4-alkyl-3-carbamoylpyridine and 4-alkyl-3,5-dicarbamoylpyridine is reported. The synthetic route developed adopts mild reaction conditions and produces target compounds in higher yields compared with methods described in literature

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Section: 6-dibromo-4-methylpyridine-35-dicarbonitrile (9a)mentioning

confidence: 99%

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

Rienzo¹,

Mellini²,

Tortorella³

et al. 2010

Synthesis

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ChemInform Abstract: DIHYDROPYRIDINE 24. MITT. PARTIELLE HYDRIERUNG EINIGER 3,5‐DICYAN‐PYRIDINE

Kuthan¹,

Musil²,

Kohoutová³

1972

Chemischer Informationsdienst

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EA‐Massenspektren Cyansubstituierter Heterocyclen

Holzmann

Rothkopf

1978

Org. Mass Spectrom.

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The negative ion mass spectrrr of cyan0 substituted heterocyclic compounds show specific fragmentation pathways which are of analytical importance for the distinction hetween isomeric compounds. All the compounds examined fragment directly to give [(CN)&, [ C d J or [C4N4]: ions. The ion structures involved were determined by the analysis of the metastable transitions and collisional activation spectra. The fragmentations of tetracyano substituted heterocyclic componnds are explained by rearrangement processes of the molecular anions. Die EA-Spektren cyansubstituierter Heterocyclen zeigen spezifische Fragmentierungen, die eine massenspektrometrische Untersclheidung isomerer Systeme gestatten. Die Strukturen der aus den Molekulanionen bzw. [(M-H):]--Ionen direkt gebildeten [(CN)J, [C4N3]--und [C4N4]T-Ionen werden durch Vergleich der MIbzw. CA-spektren verschiedener Vorlauferionen untersucht. Das Fragmentierungsverhalten von Tetracyan-substituierten Heterocyclen setzt Umlagerungen der Molekulanionen voraus.

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On dihydropyridines. XXIV. Partial hydrogenation of some 3,5-dicyanopyridines

Cited by 3 publications

References 0 publications

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

Facile and Efficient Synthesis of 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridines as Nicotinamide Mimetics

ChemInform Abstract: DIHYDROPYRIDINE 24. MITT. PARTIELLE HYDRIERUNG EINIGER 3,5‐DICYAN‐PYRIDINE

EA‐Massenspektren Cyansubstituierter Heterocyclen

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