Given a set $${\mathcal {F}}$$
F
of graphs, we call a copy of a graph in $${\mathcal {F}}$$
F
an $${\mathcal {F}}$$
F
-graph. The $${\mathcal {F}}$$
F
-isolation number of a graph G, denoted by $$\iota (G,{\mathcal {F}})$$
ι
(
G
,
F
)
, is the size of a smallest set D of vertices of G such that the closed neighborhood of D intersects the vertex sets of the $${\mathcal {F}}$$
F
-graphs contained by G (equivalently, $$G - N[D]$$
G
-
N
[
D
]
contains no $${\mathcal {F}}$$
F
-graph). Thus, $$\iota (G,\{K_1\})$$
ι
(
G
,
{
K
1
}
)
is the domination number of G. For any integer $$k \ge 1$$
k
≥
1
, let $${\mathcal {F}}_{1,k}$$
F
1
,
k
be the set of regular graphs of degree at least $$k-1$$
k
-
1
, let $${\mathcal {F}}_{2,k}$$
F
2
,
k
be the set of graphs whose chromatic number is at least k, and let $${\mathcal {F}}_{3,k}$$
F
3
,
k
be the union of $${\mathcal {F}}_{1,k}$$
F
1
,
k
and $${\mathcal {F}}_{2,k}$$
F
2
,
k
. Thus, k-cliques are members of both $${\mathcal {F}}_{1,k}$$
F
1
,
k
and $${\mathcal {F}}_{2,k}$$
F
2
,
k
. We prove that for each $$i \in \{1, 2, 3\}$$
i
∈
{
1
,
2
,
3
}
, $$\frac{m+1}{{k \atopwithdelims ()2} + 2}$$
m
+
1
k
2
+
2
is a best possible upper bound on $$\iota (G, {\mathcal {F}}_{i,k})$$
ι
(
G
,
F
i
,
k
)
for connected m-edge graphs G that are not k-cliques. The bound is attained by infinitely many (non-isomorphic) graphs. The proof of the bound depends on determining the graphs attaining the bound. This appears to be a new feature in the literature on isolation. Among the result’s consequences are a sharp bound of Fenech, Kaemawichanurat, and the present author on the k-clique isolation number and a sharp bound on the cycle isolation number.