Auxetic structures are characterized by their unique mechanical property of exhibiting a negative Poisson's ratio, which means they expand laterally when stretched and contract laterally when compressed, contrary to conventional materials. This distinctive behavior enables auxetic materials to possess enhanced mechanical properties such as improved energy absorption, shear resistance, and indentation resistance. This study investigates the effect of cell size and shape orientation on the tension mechanical properties of auxetic structures. For this reason, a total of nine different specimens were produced using three different cell size (2-cell, 3-cell, and 4-cell) and three different shape orientations (0º, 45º, 90º) using a masked stereolithography (MSLA) printer, and their tension mechanical properties were investigated. The best cell size and shape orientation were determined by Taguchi's maximum signal-to-noise ratio (S/N) analysis, and the data was analyzed with the Analysis of Variance (ANOVA) test. The results show that auxetic structure cell size and shape orientation optimization are critical for achieving the required mechanical characteristics in 3D printed parts for diverse applications. This research contributes to optimizing MSLA 3D printing for improved mechanical performance and to the field of additive manufacturing.