On finding natural antibiotics based on TCM formulae

Gao, Pei; Nasution, Ahmad Kamal; Yang, Shuo; Chen, Zheng; Ono, Naoaki; Kanaya, Shigehiko; Altaf‐Ul‐Amin, Md.

doi:10.1016/j.ymeth.2023.04.001

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…In the ethanol extract, the presence of isosaponarin and one unidentified flavonoid was detected, as well as the phenylpropanoid glycoside II, 1-(3'',4''-dihydroxy-5''-methoxy)- O - trans -cinnamoyl-2'- O-trans -sinapoyl gentiobiose and 1- O-trans -caffeoyl-2'- O-trans -sinapoyl gentiobiose, which were not observed in the methanol-acetone–water extract. These compounds showed, among others, good radical scavenging activity against superoxide anion radicals (O •− 2 ) using ESR 9 , significant anti-tumour activity 35 , 36 , as well as antibacterial 37 and probiotic activity 38 .…”

Section: Discussionmentioning

confidence: 99%

Chemical composition of extracts from leaves, stems and roots of wasabi (Eutrema japonicum) and their anti-cancer, anti-inflammatory and anti-microbial activities

Szewczyk

Skowrońska

Kruk

et al. 2023

Sci Rep

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The purpose of our study was to evaluate the composition of the extracts obtained from the roots and leaves of Eutrema japonicum cultivated in Poland. For this purpose, LC-DAD-IT-MS and LC-Q-TOF-MS analyses were used. The results revealed the presence of forty-two constituents comprising glycosinolates, phenylpropanoid glycosides, flavone glycosides, hydroxycinnamic acids, and other compounds. Then, the resultant extracts were subjected to an assessment of the potential cytotoxic effect on human colon adenocarcinoma cells, the effect on the growth of probiotic and intestinal pathogenic strains, as well as their anti-inflammatory activity. It was demonstrated that 60% ethanol extract from the biennial roots (WR2) had the strongest anti-inflammatory, antibacterial, and cytotoxic activities compared to the other samples. Our results suggest that extracts from E. japonicum may be considered as a promising compound for the production of health-promoting supplements.

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