In the present paper, we introduce the notion of (F,G)-derivation on a lattice as a generalization of the notion of (∧,∨)-derivation. This newly notion is based on two arbitrary binary operations F and G instead of the meet (∧) and the join (∨) operations. Also, we investigate properties of (F,G)-derivation on a lattice in details. Furthermore, we define and study the notion of principal (F,G)-derivations as a particular class of (F,G)-derivations. As applications, we provide two representations of a given lattice in terms of its principal (F,G)-derivations.