On genetic information uncertainty and the mutator phenotype in cancer

Visualizing Quantum Coherence Based on Single-Molecule Coherent Modulation Microscopy

“…We also suggest that SMCM might be used to identify cell canceration, which may either be directly derived from amplified uncertainty induced by an increase in quantum and thermodynamic fluctuation or be indirectly arising from the loss of natural uncertainty reduction mechanisms. 36 To this end, further experiments will be performed by specific labeling, genetic modifications, and more controlled experiments to reveal the direct relationship between these physiological activities and quantum coherent imaging. This approach will provide a new way for cancer diagnosis and a new idea for the study of cell canceration.…”

Controlling Keto–Enol Tautomerism of Ureidopyrimidinone to Generate a Single-Quadruple AADD-DDAA Dimeric Array

“…Prototropic tautomerism, intramolecular transfer of hydrogen from one atom to another, is a common phenomenon in living systems. − Keto–enol tautomerism is a typical paradigm of intramolecular proton transfer, and it is of great significance in biochemistry. − The canonical keto form and its corresponding rare tautomeric enol form of the bases guanine and thymine exist in cells, and the tautomerism of base pairs which have different base-pairing properties increases the uncertainty of genetic information, resulting in an imprecision of the recognition, replication, and transfer of genetic information . Essentially, an intrinsic genetic instability arisen by keto–enol tautomerism in cells possibly facilitates mutation and even cancer development. − Therefore, it is extraordinarily important to study how to control keto–enol tautomerism.…”