On Haemoglobin Degradation in the Newborn

Watson, Derek; Porter, Roger S.

doi:10.1159/000207323

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…In our series no relationship could be found between anhaptoglobin emia and ABO incompatibility (table 111); these results suggest that if there is selective interaction between the ABO and Hp systems [12,18] it may be due to factors present after birth, as is suggested also by another study [25]. In addition, the following characteristics showed no effect, in our sample, in the anhaptoglobinemia of the newborn : birth weight, racial character istics of the children and of their mothers, as well as the socioeconomic level, parity and Hp type of the latter.…”

Section: Resultssupporting

confidence: 69%

Factors Influencing Anhaptoglobinemia in Newborns from Salvador, Brazil

Azevedo¹,

Salzano²,

Azevêdo³

1974

Hum Hered

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A total of 505 newborns and their mothers were studied. The frequency of classifiable haptoglobin in the cord blood was 8%, with males showing a significantly higher prevalence (10%) than females (5%). Among the infants with haptoglobin patterns at birth there was a significant excess of type 1–1, as compared with the distribution found among the mothers. The following characteristics showed no effect in the observed anhaptoglobinemia: ABO incompatibility; birth weight; racial characteristics of the babies and of their mothers; socioeconomic level, parity, and haptoglobin type of the mothers.

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Section: Resultssupporting

confidence: 69%

Factors Influencing Anhaptoglobinemia in Newborns from Salvador, Brazil

Azevedo¹,

Salzano²,

Azevêdo³

1974

Hum Hered

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“…Nevertheless, the present method seems to provide quantitative evidence of hapto globins even in the premature infant. This substantiates the suggestions of other authors [3,10,14,16] that some prematures do have detectable levels of haptoglobin present in cord blood or in the first weeks of life.…”

Section: Discussionsupporting

confidence: 92%

“…Some degree o f hemoglobin break-down seems to have occured in several instances (with a falling hematocrit before significant weight gain) and may account for part of the observed fall in values as a result of consumption of haptoglobin to form the hemoglobin-haptoglobin complex. W atson and P o rter [16] observed lower levels where cord hemoglobin was low, and also noted maximal levels in premature infants between 3 and 7 days of life.…”

Section: Discussionmentioning

confidence: 90%

Haptoglobins in the Newborn. II. Low Birth Weight Babies

Philip¹

1971

Neonatology

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“…Hp develops gradually during the first weeks of life [19] and exerts a protective action against bacterial infections [20]. Recent evidence from our laboratory suggests that in the neonatal period Hp1 develops earlier compared to other types.…”

Section: The Genetic Systems Consideredmentioning

confidence: 99%

Genetic Polymorphism and Th1/Th2 Orientation

Bottini

Gloria‐Bottini²,

Amante³

et al. 2005

Int Arch Allergy Immunol

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Background: It is likely that besides developmental and environmental factors, genetic factors also play an important role in Th1/Th2 orientation and susceptibility to related disorders. Thus, for each genetic factor involved one would expect an opposite pattern of susceptibility towards Th1- and Th2-associated diseases. Methods: We report a comparative analysis of the pattern of association of four genetic polymorphisms with bronchial asthma (Th2 disease) and Crohn’s disease (CD; Th1 disease). The study population included 291 Roman children with bronchial asthma and 72 adult Romans with CD, and haptoglobin, adenosine deaminase (ADA), acid phosphatase locus 1 (ACP1) and MN phenotypes were determined. Results: Compared with controls from the same population, the pattern of phenotype association observed in bronchial asthma is exactly opposite to that observed in CD. The analysis of pairwise gametic type distribution for ACP1, ADA and MN polymorphisms has shown that the pattern of differences between bronchial asthma and controls is opposite to that observed between CD and controls. Conclusions: The pattern of differences between bronchial asthma versus CD is compatible with the hypothesis that some of the genetic systems considered contribute to Th1/Th2 orientation.

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On Haemoglobin Degradation in the Newborn

Cited by 6 publications

References 22 publications

Factors Influencing Anhaptoglobinemia in Newborns from Salvador, Brazil

Factors Influencing Anhaptoglobinemia in Newborns from Salvador, Brazil

Haptoglobins in the Newborn. II. Low Birth Weight Babies

Genetic Polymorphism and Th1/Th2 Orientation

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