On-hand tool for ammonium and urea determination in saliva to monitor chronic kidney disease – Design of a couple of microfluidic paper-based devices

Ferreira, Francisca T.S.M.; Mesquita, Raquel B. R.; Rangel, António O. S. S.

doi:10.1016/j.microc.2023.109102

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Ammonium (NH 4 + ) is another electrolyte vital for kidney functioning and infection monitoring. 45,46 Urea build-up during kidney damage can lead to slow processing of ammonia (NH 3 ), leading to elevated NH 3 concentration in the body. The main source of NH 3 in sweat is blood due to metabolic protein degradation.…”

Section: Relevance Of Sweat and Isf For Ambulatory Monitoringmentioning

confidence: 99%

Dermal-fluid-enabled detection platforms for non-invasive ambulatory monitoring

Veronica,

Li,

et al. 2023

Sens. Diagn.

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Section: Relevance Of Sweat and Isf For Ambulatory Monitoringmentioning

confidence: 99%

Dermal-fluid-enabled detection platforms for non-invasive ambulatory monitoring

Veronica,

Li,

et al. 2023

Sens. Diagn.

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“…Recently, novel colorimetric microfluidic assays have been fabricated. In this category belong the pH change-based colorimetric PADs that have been developed for chronic kidney disease biomarker detection down to the millimolar level . Ammonium and urea have been detected via a colorimetric assay by the use of the bromothymol blue indicator using saliva samples as the case of study.…”

mentioning

confidence: 99%

“…In this category belong the pH change-based colorimetric PADs that been developed for chronic kidney disease biomarker detection down to the millimolar level. 67 Ammonium and urea have been detected via a colorimetric assay by the use of the bromothymol blue indicator using saliva samples as the case of study. The PAD platform consists of 32 detection areas and 4 layers of stacked filter paper supported by a laminated pouch, as reported in Figure 5C.…”

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confidence: 99%

Paper-Based Materials for Diagnostics

Kalligosfyri,

Cinti

2024

ACS Materials Lett.

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Nowadays point-of care (POC) devices dominate the field of bioanalysis as they play a pivotal role in improving different aspects of diagnostics including screening, early diagnosis, and disease monitoring. These devices comply with the World Health Organization ASSURED criteria that describe the ideal POC tool. While conventional materials like polymers, silicon, metallic foils, and glass have been exploited in POC device manufacturing, recent innovations relying on paper-based materials have introduced a new era of versatile diagnostic tools. Because of their properties, cellulose and its derivatives have emerged as the most common paper-based substrate in device fabrication. The present review explores recent developments in paper-based diagnostics, covering a wide range of applications including reagent storage and isolation/extraction of the analyte and also serving as a sensing platform. The versatility of paper substrates in various diagnostic devices such as lateral flow assays, electrochemical sensors, microfluidics, etc. is discussed, highlighting their advantages, challenges, and limitations on the context of precision medicine.

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