In this paper, we develop the existence theory for nonlinear second-order ordinary differential equations equipped with new kinds of nonlocal non-separated type integral multi-point boundary conditions on an arbitrary domain. Existence results are proved with the aid of fixed point theorems due to Schaefer, Krasnoselskii, and Leray-Schauder, while the uniqueness of solutions for the given problem is established by means of contraction mapping principle. Examples are constructed for the illustration of the obtained results. Ulam-stability is also discussed for the given problem. A variant of the problem involving different boundary data is also discussed. Finally, we introduce an associated boundary value problem involving integro-differential equations and discuss the uniqueness of its solutions.