On how non-facetted crystals affect crystallization processes

Schiele, Simon; Meinhardt, Rolf; Friedrich, Teresa; Briesen, Heiko

doi:10.1016/j.cherd.2022.12.012

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Agglomeration, face specific growth and damage could change the morphology of the suspended crystals in a different manner than the analogue twin. Crystal morphology is closely linked to crystallization behavior. − However, in the present case study, the morphology of the suspended crystals remained similar to that of the analogue twin. Only few agglomerates were spotted in PVM images, crystals were not damaged nor faces appeared or disappeared.…”

Section: Discussionmentioning

confidence: 48%

Direct Crystal Growth Control: Controlling Crystallization Processes by Tracking an Analogue Twin

Schiele

Bier

Ommert

et al. 2023

Ind. Eng. Chem. Res.

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Due to the dynamic interactions of various crystallization phenomena, crystallization processes are notoriously difficult to control. In some applications, supersaturation control is aimed for as it affects various phenomena. Direct nucleation control aims at controlling the number of crystals in suspension.Here, we propose direct crystal growth control (DGC). The new method avoids parametrization of the thermodynamic relation between concentration, temperature, and solubility. Instead, a single crystal is fixed in the crystallization vessel, and it acts as an analogue twin. The analogue twin enables inline growth rate measurement and serves as a proxy for the growth of the suspended crystals. Via temperature manipulation, the analogue twin's growth rate can be controlled to be kept constant. Growth rate of suspended crystals is then observed to be constant, too. However, hydrodynamic conditions for the analogue twin and suspended crystals were different and need to be further explored for a more accurate application of DGC. Temperature-dependent growth rates, the existence of molecular clusters in solution, and the potential use of the new growth rate probe for parameter estimation are discussed.

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Section: Discussionmentioning

confidence: 48%

Direct Crystal Growth Control: Controlling Crystallization Processes by Tracking an Analogue Twin

Schiele

Bier

Ommert

et al. 2023

Ind. Eng. Chem. Res.

Self Cite

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Growth of broken crystals tracked in 4D using X-ray computed tomography and its influence on impurity incorporation

Schiele,

Haider,

Briesen

2024

Sci Rep

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Crystallization is a commonly used unit operation for separation and purification. During processing, crystals may break due to mechanical stress, e.g., intentionally by milling or unintentionally through collision with stirrers. This study investigates the growth of broken crystals in three dimensions using X-ray micro-computed tomography. The results show that damaged regions of crystals grow faster than faceted regions, and crystals become faceted through growth. Initially, this happens on a microscale, producing faceted but concave regions on the crystal surface. Eventually, crystals become convex. Shape-healing through growth incorporates inclusions in the crystals. These findings have important implications for designing and optimizing crystallization processes in the pharmaceutical, food, and chemical industries, as purity is often a critical quality criterion adversely affected by inclusions. In addition, the kinetics in crystallization processes are likely to be strongly affected by the growth of non-faceted and concave crystals.

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On how non-facetted crystals affect crystallization processes

Cited by 2 publications

References 44 publications

Direct Crystal Growth Control: Controlling Crystallization Processes by Tracking an Analogue Twin

Direct Crystal Growth Control: Controlling Crystallization Processes by Tracking an Analogue Twin

Growth of broken crystals tracked in 4D using X-ray computed tomography and its influence on impurity incorporation

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