The planimetric and altimetric accuracies of the Digital Elevation Model (DEM) obtained from Unmanned Aerial Vehicle (UAV) depend on some photogrammetric parameters such as flight height, flight speed, and/or ground sample distance. In the last few years, the study of computer vision algorithms has increased focusing on their importance on the photogrammetric reconstruction process for land surface mapping. According to this, the main goal of this paper was to evaluate the performance of different photogrammetric processing software, such as Open Drone Map (ODM), Agisoft PhotoScan, and Pix4D, on DEM accuracy. For this purpose, a DJI Phantom 4 Pro drone was used for the acquisition of 600 images in a difficult topography area (630 ha) with 27 Ground Control Points (GCP) previously established. The photogrammetric products were generated, and a statistical analysis was carried out for the comparison of the DEMs. The results of the Root Mean Square Error (RMSE) show that the planimetric and altimetric accuracy of Agisoft PhotoScan (RMSExy = 0.514 m; RMSEz = 0.162 m) is greater than those obtained using Pix4D and ODM. Unsatisfactory results were obtained with ODM since deformations and high planimetric and altimetric errors were identified in the orthomosaic and DEM, which was related to inefficient key point detection and an incomplete mosaic construction process. Agisoft PhotoScan modeled the anthropogenic objects as part of the land surface, while Pix4d smoothed the terrain, eliminating these anthropogenic objects and not considering them as part of the ground surface.