Base isolation of buildings is the most efficient way of designing seismically resistant structures. Application of seismic isolators allows mutually independent movements of the ground and the structure during earthquakes. The application of seismic isolators increases the natural period of vibrations, which reduces the seismic forces in the structure. The paper analyzes the influence of the application of lead rubber bearings on the response of the structure to the action of an earthquake. A reinforced concrete frame structure was analyzed both for the case of base isolation and rigid foundation. Based on the comparative analysis of the natural period of vibrations, base shear seismic forces, displacement of the top level of the structure and relative inter-storey drift, conclusions were drawn about the efficiency of application of this type of seismic isolator. The required amount of ductility of a structure, as well as damage to structural and non-structural elements, is greatly reduced by base isolation.