A zonal hybridization of the RNG [Formula: see text]-[Formula: see text] URANS model is proposed for the simulation of turbulent flows in internal combustion engines. The hybrid formulation is able to act as URANS, DES or LES in different zones of the computational domain, which are explicitly set by the user. The resulting model has been implemented in a commercial computational fluid dynamics code and the LES branch of the modified RNG [Formula: see text]-[Formula: see text] closure has been initially calibrated on a standard homogeneous turbulence box case. Subsequently, the full zonal formulation has been tested on a fixed intake valve geometry, including comparisons with third-party experimental data. The core of the work is represented by a multi-cycle analysis of the TCC-III experimental engine configuration, which has been compared with the experiments and with prior full-LES computational studies. The applicability of the hybrid turbulence model to internal combustion engine flows is demonstrated, and PIV-like flow statistics quantitatively validate the model performance. This study shows a pioneering application of zonal hybrid models in engine-relevant simulation campaigns, emphasizing the relevance of hybrid models for turbulent engine flows.