<p>Since the Seoul Metropolitan Area, Republic of Korea, is highly populated, a large number of people are frequently exposed to high concentrations of particulate matter (PM) with mean aerodynamic diameters of <= 10 mm (PM<sub>10</sub>) in cold season. The concentration of PM<sub>10</sub> in Seoul Metropolitan Area increases by transboundary transport, local direct emissions, and chemical reactions of aerosol precursors in the atmosphere. Here, the Seoul Metropolitan Area (Seoul, Gyeonggi-do, and Incheon) and surrounding region (Chungcheongnam-do, Daejeon, and Sejong) are regionally classified by clustering analysis based on the variability of PM<sub>10</sub> concentrations. According to the inertia score by the number of clusters, the optimum cluster number of regional variability of PM<sub>10</sub> is four. The region of cluster 1 is divided into southern Gyeonggi-do and eastern Chungcheongnam-do, the cluster 2 is mainly classified Incheon, western Gyeonggi-do, and Seoul. The cluster 3 region is western Chungcheongnam-do adjacent to Yellow Sea, and the cluster 4 is classified into eastern Gyeonggi-do. The variability of PM<sub>10</sub> in each region is distinguished by the local chemical pollutants emission and weather conditions such as wind speed and direction in each region. This regional classification of PM<sub>10</sub> variability is different from administrative districts. Considering most of policies for responding to high concentrations of PM<sub>10</sub> are being prepared by administrative districts, this study suggests that a response on the basis of these regional PM<sub>10</sub> distribution would be more effective way to improve air quality in the Seoul Metropolitan and Chungcheong Area.</p>