On-line attenuated total reflection infrared spectroscopy (ATR-IR): a powerful tool for investigating the methyl cyclopentenone synthesis process

Abstract

On-line attenuated total reflection infrared spectroscopy (ATR-IR) was used to gain a good understanding of the kinetics and mechanism for methyl cyclopentenone (MCP) synthesis from 2-methylfuran and formaldehyde in a...

Application ofin situATR-IR spectroscopy for the synthesis of bisphenol F: optimization, mechanistic and kinetics studies

“…As a non-destructive and noninvasive detecting technology, ATR-IR spectroscopy can be employed to monitor the variation in material concentration in situ without contamination, especially under rigorous experimental conditions. Thus, it is used widely to study surface characteristics, [19][20][21][22][23][24] and gain insight into reaction processes and mechanisms [25][26][27][28][29][30][31][32][33] in chemical engineering, environmental engineering and pharmaceutical research. For example, the mechanism for the catalytic ozonation of clobric acid under ambient conditions was explored systematically with ATR-IR spectroscopy.…”

An in-depth mechanistic study of the p-hydroxyphenylglycine synthetic process using in situ ATR-IR spectroscopy

“…It acts as a powerful tool for counterfeit drug detection, quantication of formulations, polymorph analysis, stability test, intact dosage forms, nal product quality control and other important areas. [17][18][19][20][21][22][23][24][25][26][27][28][29] The non-invasive and non-destructive characteristics of ATR-IR eliminate the possibility of target destruction and contamination, and therefore, it is a promising Process Analytical Technology (PAT), particularly under rigorous environments. By monitoring the intensity of each characteristic peak in real-time, we can precisely point out the reaction endpoint, make instant feedback and get a deep understanding of the reaction mechanism in a continuous production process.…”