On‐line multidimensional chromatography using packed capillary liquid chromatography and capillary gas chromatography

Cortes, Hernan J.; Pfeiffer, C. D.; Richter, Bruce E.

doi:10.1002/jhrc.1240080823

Cited by 80 publications

(27 citation statements)

References 18 publications

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“…Typically, LC is used to perform a cleanup separation, whereas GC is used in the final analysis of the portion of the matrix containing the analyte of interest. Although microcolumn LC-GC is a relatively new technique, a number of methods relying on this technology have been developed (17,(19)(20)(21)(22)(23)(24)(25)(26).…”

Section: Resultsmentioning

confidence: 99%

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Supercritical fluid extraction of chlorpyrifos methyl from wheat at part per billion levels

Campbell

Meunier

Cortes

1989

J Microcolumn Separations

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Abstract. The use of supercritical fluid extraction (SFE) to recover pesticides from environmental matrices was investigated using chlorpyrifos methyl spiked on a wheat kernel substrate. Volume-based extraction recovery profiles were generated to determine the pressure, temperature, and fluid composition that yielded the maximum analyte recovery and minimum extraction time. On-line coupled microcolumn liquid chromatography-gas chromatography (LC-GC) with electron capture detection was used to effect cleanup of the extracts and to determine the recoveries of chlorpyrifos methyl.With unmodified CO, as the extraction solvent, we obtained only 65% recovery of chlorpyrifos methyl spiked at the 50 parts per billion (ppb) level on the wheat. The use of CO, mixed with 2% methanol, however, yielded recoveries averaging 97.8%, with a relative standard deviation of 4.0%. Extraction times were 10 min or less for a 1-g sample size. The use of PEEK sealing material in the extraction vessels and in the ferrules of the finger-tight fittings in the SFE system permitted rapid cycling between multiple samples and reliable, leak-free operation. This approach could significantly shorten the sample preparation time associated with pesticide residue analysis.

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Section: Resultsmentioning

confidence: 99%

“…Wheat extracts containing chlorpyrifos methyl were analyzed by LC-GC. The LC-GC setup has been described previously (17). The LC pump was a model p,LC-500 (Isco, Lincoln, Nebraska, USA) operated in the constant flow mode.…”

Section: Methodsmentioning

confidence: 99%

Supercritical fluid extraction of chlorpyrifos methyl from wheat at part per billion levels

Campbell

Meunier

Cortes

1989

J Microcolumn Separations

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“…multidimensional chromatography. Microcolumn LC has been interfaced with thin-layer chromatography applying infrared detection [220], conventional high-performance liquid chromatography [2211, microcolumn LC [222][223][224], gas chromatography [225][226][227][228][229][230][231], supercritical fluid chromatography [232] and capillary electrophoresis [233]. The coupling of individual separation techniques increases the total peak capacity of the chromatographic system, which is equal to the product of the peak capacities of the individual dimensions.…”

Section: Multidimensional Chromatographymentioning

confidence: 99%

“…Different type of interfaces have been developed. Among them are retention gap-based interfaces, such as on-column injectors [225] and looptype interfaces [226], pyrolysis interfaces and (multicapillary) stream splitters. The retention gap-based interfaces have been applied most extensively because of their ease of use.…”

Section: Multidimensional Chromatographymentioning

confidence: 99%

Microcolumn liquid chromatography: instrumentation, detection and applications

Vissers¹,

Claessens

Cramers

1997

Journal of Chromatography A

208

101

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This review discusses many different aspects of microcolumn liquid chromatography (LC) and reflects the areas of microcolumn LC research interest over the past decades. A brief theoretical discussion on a number of major issues, such as column characterisation, chromatographic dilution effects and extracolumn band broadening in microcolumn LC is given. Recent progress in column technology and the demands and developments of instrumentation and accessories for microcolumn LC are also reviewed. Besides that, the developments in a large number of established and also more recent detection techniques for microcolumn LC are also discussed. The potential of hyphenation of microcolumn LC with other techniques, more particularly of multidimensional chromatography and microcolumn LC coupled to mass spectrometry is reviewed. Finally, the perspective of microcolumn LC separation methods is stressed by a number of relevant applications.

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“…In overcoming problems of sample complexity, the benefits of multidimensional chromatographic systems have been well demonstrated [7] since the mid 1980's [8,9].…”

Section: Introductionmentioning

confidence: 99%

On‐line LC‐GC‐AED and LC‐GC‐MS – multidimensional methods for the analysis of PAC in fuels, combustion emissions and atmospheric samples

Lewis

Askey

Holden

et al. 1997

J. High Resol. Chromatogr.

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SummaryThe composition and concentration of polycyclic aromatic compounds (PAC) in fuels, their combustion products and in the atmosphere remains a topic of considerable interest. Despite the wealth of literature on the identification of PAC, speciation at low concentrations remains difficult due to instrument limitation and the complexity of fuel and environmental samples. Consequently online sample preparation procedures (SPE, SFE, LC, etc.) are becoming an increasingly important step in the analysis procedure particularly where sample clean-up and fractionation are essential for improving analytical resolution. In this study a normal phase high pressure liquid chromatography-gas chromatography (LC-GC) system has been developed to provide quantitative analysis of samples, as diverse as coal liquids, petroleum fuels, diesel exhaust particulates and urban air particulates. Separation and identification of parent and alkylated PAH, heterocyclic, nitro-and oxy-PAC can be achieved by direct coupling to an atomic emission detector and a bench top mass spectrometer. For both systems the primary LC separation combined with the large sample volume transferred to GC vastly improves detection limits. Furthermore the complimentary nature of the two detectors used enables the positive identification of many unknowns.

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On‐line multidimensional chromatography using packed capillary liquid chromatography and capillary gas chromatography

Cited by 80 publications

References 18 publications

Supercritical fluid extraction of chlorpyrifos methyl from wheat at part per billion levels

Supercritical fluid extraction of chlorpyrifos methyl from wheat at part per billion levels

Microcolumn liquid chromatography: instrumentation, detection and applications

On‐line LC‐GC‐AED and LC‐GC‐MS – multidimensional methods for the analysis of PAC in fuels, combustion emissions and atmospheric samples

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