Guided by market orientation, the traditional mass production mode has gradually shifted to the multi-variety small-batch production mode, so it's of certain necessity and practical and theoretical value to research the logistics service quality of multi-variety small-batch production. This paper explores the quality management and control for the whole-process logistics service of multi-variety small-batch production (MVSBP) manufacturing. Firstly, the authors analyzed the factors affecting the MVSBP logistics system of production and manufacturing enterprises, and plotted the distribution paths between different functional areas in the production workshop. Then, the simulation steps of the MVSBP logistics system were detailed, and the simulation software was introduced. After that, the three elements of MVSBP logistics, namely, site selection, path design, and warehousing, were optimized, before providing the optimization objective function. Finally, the MVSBP logistics system was simulated on a real case: the production logistics management of a porcelain blank processing workshop. The simulation results demonstrate the effectiveness of our quality management and control strategy for production logistics.