On-line simultaneous determination of S- and R-perindopril using amperometric biosensors as detectors in flow systems

Electrochemical Biosensors for Drug Analysis

“…Generally, the transduction system is based on monitoring hydrogen peroxide electrooxidation. Taking advantage of the high selectivity of these enzymes, simultaneous detection of S-and R-captopril [77] or S-and R-perindopril [78] has been possible using flow injection [68] analysis with sequential injection at a rate of more than 30 samples per hour. Application to pharmaceuticals has been realized.…”

Application of sequential injection analysis to pharmaceutical analysis

“…In this work, they utilised an enantioselective membrane electrode based on maltodextrin for the potentiometric detection of S-captopril and the amperiometric sensor previously described for the determination of R-captopril. The two amperiometric detectors previously described (based on d-and l-amino acid oxidase) were also applied in the simultaneous determination of S-and R-perindopril [131]. These two detectors were incorporated in two flow analysis systems (FIA and SIA).…”

10.1007/s10809-008-1002-y

“…Membrane technologies (potentiometric sensors with polymer membranes containing a selector [6,[28][29][30]), classical biosensors (determination of optically active enzyme substrates [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]), and the whole range of techniques for the chemical modification of metal and graphite electrodes can be used for this purpose. Membrane technologies (potentiometric sensors with polymer membranes containing a selector [6,[28][29][30]), classical biosensors (determination of optically active enzyme substrates [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]…”