Development of the digital transformation of the state, the economy in general, business and society creates the need to quantify its results and assess the level of impact on the economy. The paper explains a methodological approach to calculating digital economy multipliers for territories based on the calculation of total income (direct and indirect) from digital activity. The multiplier measures the impact of the digital economy on macroeconomic and regional indicators, helps assess the extent of this impact and study its dynamics. The authors calculated digital economy multipliers for the Russian Federation and at the regional level (using the example of the Novosibirsk region) and estimated total digital sector income with a multiplier effect. The paper concludes with the contribution of digital transformation to the economic growth of the Russian Federation and the development of the Novosibirsk region about the multiplier dynamics and the ratio of direct and indirect effects in the total income of the digital sector. Rosstat data for 2017–2021 served as the information base for empirical calculations.