Entrepreneurship and supply chain management (SCM), respectively, have enjoyed meteoric rises in business practice and scholarly attention over the past three decades. Further, each of the two disciplines has much to offer the other. Yet, we have not witnessed sustained, meaningful integration of principles, practices, and influences despite powerful potential. This paper explores this potential by featuring prospects for entrepreneurship to influence SCM, and vice versa, bringing an entrepreneurial mindset to SCM and supply chain orientation (SCO) to entrepreneurial activities. In particular, we illustrate a validated assessment and diagnostic tool, the Corporate Entrepreneurship Assessment Instrument (CEAI), adapted for supply chain managers with the intent of instilling corporate entrepreneurial activity among supply chain professionals. Granted, supply chain managers are typically tasked with meeting expectations toward customer service effectiveness, efficiency, asset utilization, and safety. Yet, we believe that forming an organizational environment conducive to entrepreneurial thinking could be extremely valuable in the supply chain realm, enhancing capabilities like agility, plasticity, and responsiveness such that innovation and business growth are achieved alongside traditional SCM expectations. Further, we feature several avenues for future research at the interface of entrepreneurship and SCM.