<abstract><p>Recently, coupled systems of fractional differential equations play a central role in the modelling of many systems in e.g., financial economics, ecology, and many more. This study investigates the existence and uniqueness of solutions for a nonlinear coupled system of fractional differential equations involving Riemann-Liouville and Caputo derivatives with coupled Riemann-Stieltjes integro-multipoint boundary conditions. The main tools are known fixed point theorems, namely, Leray-Schauder alternative, Banach fixed point theorem, and the Krasnoselskii fixed point theorem. The new system, which can be considered as a generalized version of many previous fascinating systems, is where the article's novelty lies. Examples are presented to illustrate the results. In this way, we generalize several earlier results.</p></abstract>