Abstract. Excitation and measurement mode of Electrical Resistance Tomography (ERT) system would determine the sensitivity, information quantity and noise immunity of the test field. In this paper, a 16-electrode ERT system is cited to conduct a research on 8 excitation modes and 2 measurement modes by numerical analysis. The independent data volume, equipotential line distribution, as well as amplitude and sensitivity characteristics of measured voltage are separately compared. Considering the overall various factors, Mode7 and the reference measurement mode are considered to be the best choices.