On para‐endocrine cancer syndromes

Goodall, C. M.

doi:10.1002/ijc.2910040102

Cited by 31 publications

(7 citation statements)

References 76 publications

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“…Only in one study, para-endocrine activity (ACTH hypersecretion) of bronchogenic carcinoma of oat cell type was found minimal with 2.8% [55]. These findings, however, are not in agreement with other reports [39] and have not yet been confirmed. In contrast, albeit Cushing's disease was absent, about 30% of lung cancer patients had an ACTH-producing tumor [47] indicating and stressing the importance of measurement of para-endo crine activity for early diagnosis, prognostic, and therapeutic evaluation.…”

Section: Diagnostic Prognostic and Therapeutic Implications Of contrasting

confidence: 54%

“…At present, the 'abnormal gene action theory', also termed 'gene de repression theory' [33,39,77], considering disturbance in repression of undesired gene information and gene control in some cancer types as the cause for para-endocrine activity, is favored by many. Accordingly, malig nancy can be induced for instance by carcinogens such as polycyclic hydro carbons, hormones (estrogens, diethylstilbestrol), and oncogenic viruses of DNA and RNA type; within the course of this process of malignant de generation and growth, the immunologic status of the host also plays a major role.…”

Section: // Mechanisms Involved In Development O F Para-endocrine Tumentioning

confidence: 99%

“…Diagnostic and therapeutic means such as intracellular localization of gonadotropins by immuno fluorescence [8,23] or even administration of gonadotropin antiserum or other antisera directed against respective para-endocrine tumor activity may prove to be useful diagnostic and therapeutic procedures not only in such animal tumors, but also in hormonally active human cancers. Also anahormones -chemically modified hormones which have lost their hormonal activity while they have retained their antigenic specificity and binding affinity to respective hormonal target cells -may be investigated in regard to their possible placement in para-endocrine tumor diagnostic and treatment [39], Anahormones are prepared from respective normal hormones (HGH, ACTH, insulin, gonadotropins) by iodination, acetylation, and oxidation [59] and they can compete with the respective native hormone. Because paraendocrine hormones may support growth and malignant potentials of their 410 VORHERR own tumor cells, anahormones may prove useful in locating ectopically active tissues and inhibiting their growth.…”

Section: Diagnostic Prognostic and Therapeutic Implications Of mentioning

confidence: 99%

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Para-Endocrine Tumor Activity with Emphasis on Ectopic ADH Secretion

Vorherr¹

1974

Oncology

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Evidence has accumulated by biochemical, histologic, tissue incubation and tissue culture studies that some malignant tumors may synthesize substances which are either biologically and immunologically closely related to or identical with the respective natural hormone. Hormone measurements in blood and urine reflect the production rates in tumor tissue; ectopic hormone secretion by tumor cells is capable of raising respective plasma and urinary hormone concentrations several fold above normal. Hormone estimates (antidiuretic hormone, adrenocorticotrophic hormone, gonadotropins, etc.) in high risk subjects (heavy smokers, etc.) may contribute to early diagnosis of lung cancer and support therapeutic and prognostic evaluation of the cancer patient.

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Section: Diagnostic Prognostic and Therapeutic Implications Of contrasting

confidence: 54%

Section: // Mechanisms Involved In Development O F Para-endocrine Tumentioning

confidence: 99%

Section: Diagnostic Prognostic and Therapeutic Implications Of mentioning

confidence: 99%

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Para-Endocrine Tumor Activity with Emphasis on Ectopic ADH Secretion

Vorherr¹

1974

Oncology

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“…Endocrine tumors include thyroid, adrenal, pancreas, parathyroid, and pituitary glands (1). Thyroid cancers are classified into four main types: papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), medullary thyroid cancer (MTC), and anaplastic thyroid cancer (ATC) (2, 3).…”

Section: Introductionmentioning

confidence: 99%

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

et al. 2019

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Background & Objective:Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior.Methods:In this research, we determined the promoter methylation status of four tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For methylation, we used the methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls.Results:Our data showed that the promoter methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0.05. The most significant differences were observed in RASSF1; 77.2% of hyper-methylated PTC patients versus 15.6% hyper-methylated goiter samples (P<0.001). Conclusion:RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.

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“…Table II provides a brief summary of some of the proteins formed in tumours arising from tissues which do not normally make them or, alternatively, make them in undetectable amounts. Para-endocrine cancer syndromes have been recognized clinically for many years (see Goodall, 1969 Besides the examples quoted, evidence for abnormal synthesis of antidiuretic hormone, melanin-stimulating hormone, and gonadatrophic hormone have been reported. Some tumours may even secrete several different hormones.…”

mentioning

confidence: 99%