On pharmacologist and vaccines: Present and future challenges

Pellegrino, Paolo; Capuano, Annalisa; Radice, Sonia

doi:10.1016/j.phrs.2014.10.010

Cited by 2 publications

(6 citation statements)

References 7 publications

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“…These and other observations [21,27] strongly suggest an immune-mediated mechanism by which vaccines interfere with drug metabolism.…”

Section: Cytokines and Cytochromessupporting

confidence: 65%

“…The role of genetic predisposition in the risk of occurrence of vaccine-related adverse reactions has been discussed largely in recent years [21,50,77,78], with special emphasis on the ''ASIA-Autoimmune/inflammatory Syndrome Induced by Adjuvants'' [79]. The term ''ASIASyndrome'' was coined in 2011 to describe the spectrum of immune-mediated diseases triggered by an adjuvant stimulus [79][80][81][82][83][84][85][86].…”

Section: Discussionmentioning

confidence: 99%

“…It is widely accepted that the most likely mechanism by which vaccines interact with drugs, the so-called vaccinedrug interaction, relies on the effects of inflammatory cytokines on cytochrome P450 (CYP) regulation in the liver [16,21].…”

Section: Cytokines and Cytochromesmentioning

confidence: 99%

“…Such an evidence suggests that only drugs metabolized by CYPs affected by IFNc are interested by the vaccinedrug interaction phenomenon, thus explaining the conflicting results retrieved from the literature [16,21].…”

Section: Evidence From Clinical Practicementioning

confidence: 99%

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Vaccine–Drug Interactions: Cytokines, Cytochromes, and Molecular Mechanisms

et al. 2015

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Vaccinations are recommended throughout life to reduce the risk of vaccine-preventable diseases and their sequelae. Vaccines are often administered in patients with chronic diseases who are likely to be treated with several drugs. A growing number of clinical observations have indicated the possibility of interactions between vaccines and drugs, leading to changes in drug metabolism after vaccination. These interactions represent a significant concern because of the increasing use of vaccines in older patients who are likely to be treated with several drugs. Because of the possible implications of adverse reactions in terms of public health, several studies were performed to verify the risk posed by these interactions and to clarify the biologic mechanisms that drive these events. Of the several mechanisms proposed to be at the basis of vaccine-drug interactions, the most convincing evidence suggests a role of inflammatory cytokines on the regulation of specific cytochrome P450 enzymes in the liver. Differences in the cytochrome P450 enzymes involved in the metabolism of these drugs could explain these contrasting results and provide important insights to fully understand the clinical importance of these events. Further studies are required to verify whether vaccine-drug interactions may occur in other clinical settings, especially the ones for which patients are required to be vaccinated against specific diseases.

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“…These and other observations [21,27] strongly suggest an immune-mediated mechanism by which vaccines interfere with drug metabolism.…”

Section: Cytokines and Cytochromessupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Cytokines and Cytochromesmentioning

confidence: 99%

Section: Evidence From Clinical Practicementioning

confidence: 99%

See 2 more Smart Citations

Vaccine–Drug Interactions: Cytokines, Cytochromes, and Molecular Mechanisms

et al. 2015

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show abstract

“…The development and the increasing diffusion of new vaccination and immunisation programmes have also raised concerns about the safety of adjuvants and their immunogenicity-enhancing effect in vaccines [11][12][13][14][15][16][17][18]. The term "ASIA-Autoimmune/inflammatory Syndrome Induced by…”

Section: Introductionmentioning

confidence: 99%