On physical and antibacterial properties and drug release behavior of poly(vinyl alcohol) hydrogels: effect of drug loaded chitosan nanoparticles

Hosseini, Fereshteh; Entezam, Mehdi; Jafari, Seyed Hassan; Khonakdar, Hossein-Ali; Abdouss, Majid

doi:10.1080/03602559.2018.1520249

Cited by 6 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, they often exhibit initial rapid and burst drug release 5,6 . Various approaches including formation of physical and chemical interactions between the drug and ionic polymer chains 7 , use of interpenetrating polymer networks (IPNs) 8 , surface modi cation of hydrogels through stimuli-responsive polymers 9,10 , and incorporation of nanoparticles as a barrier, such as nanocalys 11 , or as a drug carrier system, namely chitosan nanoparticles 12,13 and nanoliposomes 5,6,14−16 , into the hydrogel have been explored to control drug release rate from hydrogel matrix.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

Jafari Jezeh,

Entezam,

Haghiralsadat

et al. 2023

J Polym Environ

View full text Add to dashboard Cite

The main objective of this research is to investigate how curcumin liposomal nanocarriers in uence the drug release behaviour of PVA/PEG hydrogels in relation to physico-mechanical properties. For this purpose, optimal nanoliposomes from drug loading and release viewpoints, prepared by the thin-lm hydration method, were incorporated into the hydrogel composition. Hydrogel samples were physically crosslinked using the freeze-thaw procedure. According to the atomic force microscopy and eldemission scanning electron microscopy observations, nanoliposomes showed a spherical morphology with an average particle size of 100 nm and narrow size distribution. The X-ray diffraction results revealed that adding nanoliposomes to the hydrogel increases the degree of PVA chains crystallinity, enhances tensile modulus and tensile strength of the hydrogel, while decreasing swelling and dehydration rates. SEM micrographs observation displayed that the porosity in the hydrogel structure in the presence of nanoliposomes increases. Nevertheless, in agreement with physical properties, drug release from nanoliposome-in-hydrogel is slower and more controlled as compared to that from free curcumin hydrogel, especially in the early stages. The MTT assay results indicated that although all hydrogel samples are non-toxic, human foreskin broblast cell proliferation on hydrogel in the presence of curcumin-loaded nanoliposomes has improved somewhat.

show abstract

Section: Introductionmentioning

confidence: 99%

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

Jafari Jezeh,

Entezam,

Haghiralsadat

et al. 2023

J Polym Environ

View full text Add to dashboard Cite

show abstract

“…Therefore, when blended with natural polymers such as proteins, it can be used to prepare membranes commonly used in tissue engineering. [ 34–36 ] Detailed examination of PVA by Weis et al. and Lang et al.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, when blended with natural polymers such as proteins, it can be used to prepare membranes commonly used in tissue engineering. [34][35][36] Detailed examination of PVA by Weis et al and Lang et al (1961) showed that PVA membrane and the patch containing PVA hydrogel could significantly reduce the number and severity of adhesion. [37,38] Besides, PVA is a biocompatible, water-soluble, and nontoxic polymer that has been widely used in the pharmaceutical and biomedical industries.…”

Section: Introductionmentioning

confidence: 99%

“…[37,38] Besides, PVA is a biocompatible, water-soluble, and nontoxic polymer that has been widely used in the pharmaceutical and biomedical industries. [34,[39][40][41] Among the many proteins, soy peptide (SP) is one of the excellent proteins, which has good solubility and can be absorbed quickly by the human body. To determine the effects of SP, Maebuchi measured changes in serum concentrations of various amino acids, finding that SP was consumed faster and more efficiently in humans than protein or amino acid mixtures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Designing Double‐Layer Multimaterial Composite Patch Scaffold with Adhesion Resistance for Hernia Repair

Zhang

et al. 2022

Macromolecular Bioscience

View full text Add to dashboard Cite

Hernia repair mesh is associated with a number of complications, including adhesions and limited mobility, due to insufficient mechanical strength and nonresorbability. Among them, visceral adhesions are one of the most serious complications of patch repair. In this study, a degradable patch with an antiadhesive layer is prepared for hernia repair by 3D printing and electrospinning techniques using polycaprolactone, polyvinyl alcohol, and soybean peptide (SP). The study into the physicochemical properties of the patch is found that it has adequate mechanical strength requirements (16 N cm −1 ) and large elongation at break, which are superior than commercial polypropylene patches. In vivo and in vitro experiments show that human umbilical vein endothelial cells proliferated well on composite patches, and showed excellent biocompatibility with the host and little adhesion through a rat abdominal wall defect model. In conclusion, the results of this study show that composite patch can effectively reduce the occurrence of adhesions, while the addition of SP in the patch further enhances its biocompatibility. It is believed that a regenerative biological patch with great potential in hernia repair provides a new strategy for the development of new biomimetic biodegradable patches.

show abstract

The Effect of Simultaneous Radical Polymerization of Poly(N-vinyl pyrrolidone)/α,ω-Bis(methacryloyloxy-poly(ethylene glycol)) on Physical Properties of Marine Polysaccharide

Enescu

Pastrana

2019

J Polym Environ

View full text Add to dashboard Cite

On physical and antibacterial properties and drug release behavior of poly(vinyl alcohol) hydrogels: effect of drug loaded chitosan nanoparticles

Cited by 6 publications

References 20 publications

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

Liposomal Nanocarriers-Loaded Poly(vinyl alcohol) (PVA)/Poly(ethylene glycol) (PEG) Hydrogels: Physico-mechanical Properties and Drug Release

Designing Double‐Layer Multimaterial Composite Patch Scaffold with Adhesion Resistance for Hernia Repair

The Effect of Simultaneous Radical Polymerization of Poly(N-vinyl pyrrolidone)/α,ω-Bis(methacryloyloxy-poly(ethylene glycol)) on Physical Properties of Marine Polysaccharide

Contact Info

Product

Resources

About