Abstract. This paper defines a generalization of the Connes-Moscovici Hopf algebra, H(1) that contains the entire Hopf algebra of rooted trees. A relationship between the former, a much studied object in noncommutative geometry, and the latter, a much studied object in perturbative Quantum Field Theory, has been established by Connes and Kreimer. The results of this paper open the door to study the cohomology of the Hopf algebra of rooted trees.Hopf algebra, renormalization, Connes-Moscovici Hopf algebra [2010]16Y30, 81T75 Connes and Moscovici define a family of Hopf algebras, H(n), on n-dimensional flat manifolds in [7]. The action of these Hopf algebras on the group of smooth functions on the frame bundle, crossed with local diffeomorphism on M , is a well studied object in non-commutative geometry.In [6], Connes and Kreimer delineate a remarkable set of similarities between the Hopf algebra of rooted trees, H rt , which is important to understanding the perturbative regularization of Quantum Field Theories (QFTs), and H(1). The Hopf algebra H(1) is defined by a Lie algebra generated by two vector fields on the orientation preserving frame bundle F + M , X and Y , and a set of linear operators {δ i |i ∈ N}. The linear operators correspond to a sub Hopf algebra of H rt , the vector field Y corresponds to the grading operator on H rt and the vector field X to the natural growth operator on H rt .While a lot is known about the cohomologies of H(n), little is explicitly known about the cohomology classes of H rt . In particular, since the Lie algebra associated to the Lie group Spec H rt is freely generated, the Hochschild cohomologies HH• (H rt ) = 0 for • > 1. There is a one to one correspondence between generators of HH 1 (H rt ) and primitive elements of H rt [1]. Many primitive elements are known, but only one element of HH 1 H rt . The one known Hochschild one co-cycle, the grafting operator B + , however, plays an important role in understanding the combinatorics underlying the Dyson Schwinger equations for perturbative QFTs [1,9,10]. Knowing more about cohomology of H rt will lead to a better understanding of the process of perturbative regularization of QFTs, as well as the deep connection between non-commutative geometry and renormalization of the same. Framing the full Hopf algebra of rooted trees in the context of H(1) is a first step in this direction. This paper introduces a generalization of H(1), H rt (1), that contains all of H rt as a sub Hopf algebra. Key to this construction is an observation by Cayley in 1881 relating rooted trees to a particular first order differential equation. We use this to generalize the natural growth operator on H rt , and thus to define a family of vector fields X t on F + M , corresponding to the generalized natural growth operators. The commutation of these vector fields X t with the element δ 1 in H(1) gives a family of linear operators δ t , each corresponding to a rooted tree t ∈ H rt . In order to build this Hopf algebra H rt (1), we have to relax the requiremen...