On‐pump CABG in a patient with severe factor V deficiency

Yousef, Sameh; Mahmood, Syed Usman Bin; Mori, Makoto; Geirsson, Arnar

doi:10.1111/hae.13809

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…FⅤ deficiency is an extremely rare autosomal recessive genetic disorder, with a reported incidence rate of approximately one in a million [ 1 , 7 ], and can be classified as congenital or acquired FⅤ deficiency. Some coagulation disorders, including factor V deficiency, are suspected if there is a history of bleeding, physical examination findings, or abnormal blood tests on preoperative screening [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Thromboelastography in Coronary Artery Bypass Grafting in a Patient With Factor Ⅴ Deficiency With Platelet Function Disorders: A Case Report and Literature Review

Kawazoe,

Tamura,

Sato

et al. 2024

Cureus

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Reports on cases of factor Ⅴ (FⅤ) deficiency complicated by platelet function disorders in patients undergoing cardiac surgery are rare, and the utilization of thromboelastography in such cases is limited. This case presents a unique case of FⅤ deficiency complicated by platelet function disorders, highlighting the significance of tailored transfusion strategies guided by thromboelastography (TEG). A 64-year-old hemodialysis patient who was diagnosed with FⅤ deficiency 24 years prior presented for an on-pump coronary artery bypass graft. The decrease in FⅤ activity on preoperative examination was mild. Based on this finding, it was determined that preoperative fresh frozen plasma supplementation was not required. However, the case was complicated by platelet function disorders; therefore, a preoperative transfusion of platelet concentrate was performed to correct the decreased platelet function, enabling subsequent surgery. Intraoperative and postoperative transfusion strategies were guided by TEG. This study highlights TEG-guided transfusion management as a viable option for patients with FⅤ deficiency complicated by platelet function disorders.

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Section: Discussionmentioning

confidence: 99%

Use of Thromboelastography in Coronary Artery Bypass Grafting in a Patient With Factor Ⅴ Deficiency With Platelet Function Disorders: A Case Report and Literature Review

Kawazoe,

Tamura,

Sato

et al. 2024

Cureus

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“…Off‐pump CABG might be ideal for hematological disorder to maintain the factor V activity at a constant value. However, we successfully managed a case of severe factor V deficiency by replacing the coagulation factor under CPB 7 . Perioperatively strategic planned platelet and FFP or cryoprecipitates transfusion would help to increase the coagulation factor value to achieve hemostasis.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the scheduled transfusion strategy for factor V deficiency with platelet dysfunction during coronary artery surgery

Morita

Mutsuga

Uchida

et al. 2022

Journal of Cardiac Surgery

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Background Factor V deficiency is a rare disease, with an incidence of one in a million. Symptoms are mostly scant, and it is often diagnosed by the presence of an abnormality on PT‐INR or APTT. In addition, no established therapy exists and platelet dysfunction is seldom found to be concomitant with this disease Case Presentation A 64‐year‐old man who had both factor V deficiency and platelet dysfunction had angina in the past year. Coronary surgery was required, and we successfully performed coronary artery bypass grafting under strategic planned platelet transfusion with additional adequate cryoprecipitates transfusion. No perioperative problems nor any postoperative major bleeding issues were observed. The postoperative course was also uneventful. Conclusion Strategic planned platelet transfusion with the additional transfusion of an adequate amount of cryoprecipitates is thus considered to be feasible for cases presenting with factor V deficiency and platelet dysfunction.

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Factor V Deficiency (Owren's Disease) in a Patient at High Risk for Transfusion-Associated Circulatory Overload and Bleeding During Laser Lead Extraction

Fitzsimons

Barrett

Streckenbach

et al. 2022

Journal of Cardiothoracic and Vascular Anesthesia

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On‐pump CABG in a patient with severe factor V deficiency

Cited by 3 publications

References 6 publications

Use of Thromboelastography in Coronary Artery Bypass Grafting in a Patient With Factor Ⅴ Deficiency With Platelet Function Disorders: A Case Report and Literature Review

Use of Thromboelastography in Coronary Artery Bypass Grafting in a Patient With Factor Ⅴ Deficiency With Platelet Function Disorders: A Case Report and Literature Review

Effectiveness of the scheduled transfusion strategy for factor V deficiency with platelet dysfunction during coronary artery surgery

Factor V Deficiency (Owren's Disease) in a Patient at High Risk for Transfusion-Associated Circulatory Overload and Bleeding During Laser Lead Extraction

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