The aim of this paper is to bring together the properties of quasi-exact sequences and homomorphism functors. It is of interest to know whether the left quasi-exact sequences have some interesting properties related to the functors and vice versa. Moreover, we also define the dualization of left quasi-exact sequences, i.e. right quasi-coexact sequences. Our proofs show that the quasi-exactness of sequences is preserved by any homomorphism functors.