We derive necessary and sufficient conditions for an ambiskew polynomial ring to have a Hopf algebra structure of a certain type. This construction generalizes many known Hopf algebras, for example U (sl 2 ), U q (sl 2 ) and the enveloping algebra of the three-dimensional Heisenberg Lie algebra. In a torsion-free case we describe the finite-dimensional simple modules, in particular their dimensions, and prove a Clebsch-Gordan decomposition theorem for the tensor product of two simple modules. We construct a Casimir type operator and prove that any finite-dimensional weight module is semisimple.