Future space missions are going to require a few large focal planes with many sensing arrays and hundreds of millions of pixels all read out at high data rates , . This will place unique demands on the electrical and electronics (EE) subsystem design and it will be critically important to have high technology readiness level (TRL) EE concepts ready to support such missions. One such mission is the Joint Dark Energy Mission (JDEM) charged with making precise measurements of expansion rate of the universe to reveal vital clues about the nature of dark energy -a hypothetical form of energy that permeates all of space and tends to increase the rate of expansion. One of three JDEM concept studies -the Dark Energy Space Telescope (DESTINY) was conducted in 2008 at the NASA's Goddard Space Flight Center (GSFC) in Greenbelt, Maryland. This paper presents the EE subsystem framework, which evolved from the DESTINY science instrument study. It describes the main challenges and implementation concepts related to the design of an EE subsystem featuring multiple focal planes populated with dozens of large arrays and millions of pixels. The focal planes are passively cooled to cryogenic temperatures (below 140 K). The sensor mosaic is controlled by a large number of Readout Integrated Circuits and Application Specific Integrated Circuits -the ROICs/ASICs in near proximity to their sensor focal planes. The ASICs, in turn, are serviced by a set of warm EE subsystem boxes performing Field Programmable Gate Array (FPGA) based digital signal processing (DSP) computations of complex algorithms, such as sampling-upthe-ramp algorithm (SUTR), over large volumes of fast data streams. The SUTR boxes are supported by the Instrument Control/Command and Data Handling box (ICDH Primary and Backup boxes) for lossless data compression, command and low volume telemetry handling, power conversion and for communications with the spacecraft. This paper outlines how the JDEM DESTINY instrument EE subsystem can be built now, a design that is generally applicable to a wide variety of missions using large focal planes with large mosaics of sensors.