2008
DOI: 10.1016/j.jaut.2007.12.001
|View full text |Cite
|
Sign up to set email alerts
|

On reversing the persistence of memory: Hematopoietic stem cell transplant for autoimmune disease in the first ten years

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
20
0

Year Published

2008
2008
2010
2010

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 33 publications
(20 citation statements)
references
References 130 publications
(98 reference statements)
0
20
0
Order By: Relevance
“…[4][5][6] The concept of using SCT for treatment of refractory autoimmune disorders was introduced to medical practice after early encouraging data in animal models. [7][8][9] In autoimmune conditions, disease arises from failure to inhibit polyclonal expansion and activation upon exposure to self-Ags that results from a failure of normal mechanisms to suppress proliferation in the presence of innocuous or self-Ags. 8,9 The rational behind using SCT is based on ablation of clonal memory cells by cytotoxic drugs followed by introduction of stem cells for immune reconstitution, or an 'immune reset'.…”
Section: Discussion and Review Of Literaturementioning
confidence: 99%
See 3 more Smart Citations
“…[4][5][6] The concept of using SCT for treatment of refractory autoimmune disorders was introduced to medical practice after early encouraging data in animal models. [7][8][9] In autoimmune conditions, disease arises from failure to inhibit polyclonal expansion and activation upon exposure to self-Ags that results from a failure of normal mechanisms to suppress proliferation in the presence of innocuous or self-Ags. 8,9 The rational behind using SCT is based on ablation of clonal memory cells by cytotoxic drugs followed by introduction of stem cells for immune reconstitution, or an 'immune reset'.…”
Section: Discussion and Review Of Literaturementioning
confidence: 99%
“…[7][8][9] In autoimmune conditions, disease arises from failure to inhibit polyclonal expansion and activation upon exposure to self-Ags that results from a failure of normal mechanisms to suppress proliferation in the presence of innocuous or self-Ags. 8,9 The rational behind using SCT is based on ablation of clonal memory cells by cytotoxic drugs followed by introduction of stem cells for immune reconstitution, or an 'immune reset'. 9,10 Because the first report of successful autologous SCT procedure for systemic lupus erythematosus (SLE) by Marmont et al, 11 many larger studies have shown the beneficial effect of both autologous and allogeneic SCT in SLE and other autoimmune disorders such as rheumatoid arthritis (RA) systemic sclerosis, inflammatory bowel disease and autoimmune thyroiditis.…”
Section: Discussion and Review Of Literaturementioning
confidence: 99%
See 2 more Smart Citations
“…There are also discussions of the use of autoantibodies to treat malignancies. We will not discuss this literature but note several recent citations [49][50][51][52][53][54][55].…”
Section: Discussionmentioning
confidence: 99%