Controlling time-delayed processes is one of the challenges in today’s process industries. If the multi-input/multi-output system is dynamically coupled, the delay problem becomes more critical. In this paper, a new method based on Smith’s predictive method, with the help of a type-2 fuzzy system to control the system with the mentioned features, is presented. The variability in the time delay, the existence of disturbances and the existence of structural and parametric uncertainty lead to the poor performance of the traditional Smith predictor. Even if the control system is set up correctly at the beginning of the setup, it will eventually wear out, and the above problems will appear. Therefore, computational intelligence is used here, and by updating the parameters of the control system at the same time as the system changes, the control system adapts itself to achieve the best performance. To evaluate the proposed control system, a complex process system is simulated, the results of which show the good performance of Smith’s prediction method based on a type-2 fuzzy system.