On Route to Diverse Nitrogen‐Bridged Polyhetero‐cycles with an N(acyl), N(aryl)‐acetal Core

Abstract

An expeditious assembling of fused poly‐heterocyclic structures having a N(Acyl), N(aryl)‐Acetal core has been accomplished by cascade reaction of ortho‐functionalized anilines with 2‐formylbenzonitrile and subsequent intramolecular N‐amidic cyclization on different electrophilic carbons. The syntheses have been finalized using both cathodically‐initiated and conventional base‐catalyzed methods and comparing the two approaches in terms of substrate/product scope, efficiency, energy‐saving and sustainability in general.