Multiplicative hyperrings are an important class of algebraic hyperstructures which generalize rings further to allow multiple output values for the multiplication operation. Let
R
be a commutative multiplicative hyperring. A proper hyperideal
I
of
R
is called 2-prime if
x
∘
y
⊆
I
for some
x
,
y
∈
R
, then,
x
2
⊆
I
or
y
2
⊆
I
. The 2-prime hyperideals are a generalization of prime hyperideals. In this paper, we aim to study 2-prime hyperideals and give some results. Moreover, we investigate
δ
-2-primary hyperideals which are an expansion of 2-prime hyperideals.