The purpose of the present qualitative multiple case study was to identify and describe sustainability efforts and the perceptions of sustainability managers of selected higher education institutions (HEIs) in Texas. Through a Qualtrics survey and semi-structured interviews, sustainability managers shared their experiences regarding the implementation of sustainable initiatives on their campuses. The present study identified four broad themes including Organizational and Leadership Challenges and the Impact They Can Have on Sustainability, Facilities Challenges and Their Impact on Sustainability, Issues with Full Buy-In on the Part of Stakeholders, and Sustainability Personnel Knowledge and Experience. The results of the present study are considered, and recommendations are provided to help researchers identify challenges to implementing sustainability initiatives on HEI campuses.