On-site fabrication of injectable 131I-labeled microgels for local radiotherapy

Kim, Sodam; Yim, Sang Gu; Chandrasekharan, Ajeesh; Seong, Keum Yong; Lee, Tae Wook; Kim, Byeongyeon; Kim, Keunyoung; Choi, Sungyoung; Yang, Seung Yun

doi:10.1016/j.jconrel.2020.03.046

Cited by 19 publications

(16 citation statements)

References 38 publications

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“…Kim et al. [ 95 ] were able to overcome these limitations by developing locally injectable hydrogel microspheres based on microfluidic high‐throughput droplet generators and 131I‐labeled photocrosslinkable hyaluronic acid. This method can quickly produce radioactive, injectable, and biodegradable HA microspheres on site, providing it with good local retention and predictable radioactivity, enabling this method to be used for immediate treatment.…”

Section: Drug Deliverymentioning

confidence: 99%

Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

Zhao

Wang

et al. 2021

Adv Funct Materials

176

107

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Microfluidic hydrogel microspheres have been broadly studied across a wide range of industries and applications, and their use in the medical field, including control cells and drug delivery, is increasing. The usual design of these materials is intended to enable the efficient and smart encapsulation of cells and/or drugs in microspheres in which the functionalities and features are effectively controlled, lending itself some unique properties. These characteristics promote exchanges and cooperation in multiple disciplines and boost the development of precision medicine, new manufacturing technologies, and applied materials. This review begins with a discussion of microfluidic hydrogel microspheres and then introduces the preparation equipment, main principles, and related characteristics of the microspheres. Furthermore, the medical applications of microfluidic hydrogel microspheres for delivering cells and drugs are emphasized. Finally, this review discusses perspectives and future directions for accelerating the development and application of microfluidic hydrogel microspheres for controlled delivery.

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Section: Drug Deliverymentioning

confidence: 99%

Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

Zhao

Wang

et al. 2021

Adv Funct Materials

176

107

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“…Microsphere/liposome compositive system could penetrate the dense cartilage matrix to deliver drugs for OA treatment. Kim et al [44] encapsulated 131 I, a β-and γ-emitting radioisotope, into the HAMA microfluidic microspheres to target tissue for radiotherapy. 131 I-labeled HAMA was prepared by introducing N-(3-Aminopropyl)imidazole (API) groups into HAMA polymeric chains via amidation reaction, and iodinating API moiety in HAMA via chloramine T-catalyzed electrophilic aromatic substitution reaction.…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Biomaterials for microfluidic technology

Chen

Zhang

et al. 2022

Mater. Futures

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Micro/nanomaterial-based drug and cell delivery systems play an important role in biomedical fields for their injectability and targeting. Microfluidics is a rapidly developing technology and has become a robust tool for preparing biomaterial micro/nanocarriers with precise structural control and high reproducibility. By flexibly designing microfluidic channels and manipulating fluid behavior, various forms of biomaterial carriers can be fabricated using microfluidics, including microspheres, nanoparticles and microfibers. In this review, recent advances in biomaterials for designing functional microfluidic vehicles are summarized. We introduce the application of natural materials such as polysaccharides and proteins as well as synthetic polymers in the production of microfluidic carriers. How the material properties determine the manufacture of carriers and the type of cargoes to be encapsulated is highlighted. Furthermore, the current limitations of microfluidic biomaterial carriers and perspectives on its future developments is presented.

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“…2B). 33,34,45,46,50,[102][103][104] In the case of clinical EBRT equipment, the small customizable dimensions of microfluidic devices also allow clinically relevant on-chip radiation dose measurement and on-chip treatment duration, which are especially important for quantitative correlations in efficacy and toxicity studies (Fig. 2B and C).…”

Section: Sources For Radiation Therapy Modality/techniquementioning

confidence: 99%