Let ϕ be Euler's phi function. Let n be a square-free positive integer such that gcd(n, ϕ(n)) = q, q a prime, and if p | n is prime, then q 2 (p − 1). We prove that a vertex-transitive graph Γ of order n is isomorphic to a Cayley graph of order n if and only if Aut(Γ ) contains a transitive solvable subgroup.We define a new class of graphs, which are natural generalizations of metacirculant graphs (see Definition 1.23 for the definition of this class), and will call semimetacirculant graphs. We show that for square-free integers n such that gcd(n, ϕ(n)) = q a prime, a vertex-transitive Γ of order n is isomorphic to a semimetacirculant graph if and only if Aut(Γ ) contains a transitive solvable subgroup (Corollary 4.2). We also show that there exist semimetacirculant graphs Γ of order pqr, for suitable choices of p, q, and r distinct primes, that are not isomorphic to metacirculant graphs of order pqr (Theorem 4.12). As corollaries, we will make contributions to two problems posed in the literature. Chronologically, the first problem was posed by Alspach and Parsons [2]. They asked for necessary and sufficient conditions for a vertex-transitive graph Γ to be isomorphic to an (m, n)-metacirculant graph. Let n be a square-free positive integer such that gcd(n, ϕ(n)) = q a prime, but q 2 (p − 1) for any prime p | (n/q). We will show that a vertex-transitive graph Γ of order n is isomorphic to a (q, n/q)-metacirculant graph if and only if Aut(Γ ) contains a transitive solvable subgroup (Corollary 4.6). We remark that for these values of n, it was shown by Alspach and Parsons [2] that a (q, n/q)-metacirculant graph is necessarily * Fax: +1 662 325 0005.