On Some Characteristics and Biologic Functions of the Skin Surface

Sulzbebger, M.B.; Herrmann, F.

doi:10.1159/000255113

Cited by 9 publications

(2 citation statements)

References 21 publications

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“…Malkinson and Ferguson [4] first suggested this concept but as Vickers [1] points out their data could be explained by a slow diffusion process through the stratum corneum. Potential sites for this depot were suggested to be keratin spaces, follicular openings and surface folds [5]. The first definitive evidence of a stratum corneum depot for topical corticosteroids was presented by Vickers in 1963 [6].…”

Section: Historical Perspective On the Stratum Corneum Reservoir For mentioning

confidence: 99%

Factors Affecting the Formation of a Skin Reservoir for Topically Applied Solutes

Roberts

Cross

Anissimov³

2003

Skin Pharmacol Physiol

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The reservoir function of the skin is an important determinant of the duration of action of a topical solute. The reservoir can exist in the stratum corneum, in the viable avascular tissue (viable epidermis and supracapillary dermis) and in the dermis. A steroid reservoir in the stratum corneum has been demonstrated by the reactivation of a vasoconstrictor effect by occlusion or application of a placebo cream to the skin some time after the original topical application of steroid. Other solutes have also been reported to show a reservoir effect in the skin after topical application. A simple compartmental model is used to understand why reactivation of vasoconstriction some time after a topical steroid application shows dependency on time, topical solute concentration and the product used to cause reactivation. The model is also used to show which solutes are likely to show a reservoir effect and could be potentially affected by desquamation, especially when the turnover of the skin is abnormally rapid. A similar form of the model can be used to understand the promotion of reservoir function in the viable tissue and in the dermis in terms of effective removal by blood perfusing the tissues.

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Section: Historical Perspective On the Stratum Corneum Reservoir For mentioning

confidence: 99%

Factors Affecting the Formation of a Skin Reservoir for Topically Applied Solutes

Roberts

Cross

Anissimov³

2003

Skin Pharmacol Physiol

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“…Einige Autoren vertreten die Ansicht, daß cs sich um eine Verteilungsstörung der Schweiß antw ort und ihrer Nervenregulation handelt [25], (Beugenhyper hidrose bei der Neurodermitis) [26]; andere nehmen an, daß es durch sofortiges Einsaugen des ausgeschiedenen Schweißes in die H aut oberfläche am O rte des zukünftigen pathologischen Prozesses zu scheinbarer Hypohidrose kommt. Verminderte Talgmenge und er höhte Benetzungsfähigkeit könnten Verschluß der Schweißporen durch Quellung hervorrufen [27,28,29,30]. Es fehlt auch nicht die Ansicht, daß die so verursachte Schweißretention sich irgendwie an der E ntstehung des weißen Dermographismus [2,31] Um festzustcllen, ob die Hyperhidrose der neurodermitischen Hautmorphe ebenso wie die ekkrine Schweiß-Sekretion auf der gesunden Haut durch Atropin inhibiert wird, haben wir folgenden Versuch durchgeführt:…”

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