The purpose of this article is to present some new nonlinear retarded integral inequalities which can be utilized to study the existence, stability, boundedness, uniqueness, and asymptotic behavior of solutions of nonlinear retarded integro-differential equations, and these inequalities can be used in the symmetrical properties of functions. These inequalities also generalize some former famous inequalities in the literature. Two examples as applications will be provided to demonstrate the strength of our inequalities in estimating the boundedness and global existence of the solution to initial value problems for nonlinear integro-differential equations and differential equations which can be seen in graphs. This research work will ensure opening new opportunities for studying nonlinear dynamic inequalities on a time-scale structure of a varying nature.