On stiffness of scaffolds for bone tissue engineering—a numerical study

Sturm, Stefan; Zhou, Shiwei; Mai, Yiu‐Wing; Li, Qing

doi:10.1016/j.jbiomech.2010.02.020

Cited by 92 publications

(36 citation statements)

References 31 publications

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“…We used a collagen sponge to provide scaffolding and to maintain space, as both functions are essential for successful tissue regeneration (Sturm et al. , Chen et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…4). We used a collagen sponge to provide scaffolding and to maintain space, as both functions are essential for successful tissue regeneration (Sturm et al 2010, Chen et al 2011. When the periosteal tunnel architecture is maintained and the periosteum tented away from the maxillary crest with a collagen sponge, bone formation can occur (Fig.…”

Section: Periosteal Characteristics Differ With Anatomical Locationmentioning

confidence: 99%

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The potential for vertical bone regeneration via maxillary periosteal elevation

Mouraret

Kaeppler

Bardet

et al. 2014

J Clinic Periodontology

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“…We used a collagen sponge to provide scaffolding and to maintain space, as both functions are essential for successful tissue regeneration (Sturm et al. , Chen et al. ).…”

Section: Discussionmentioning

confidence: 99%

Section: Periosteal Characteristics Differ With Anatomical Locationmentioning

confidence: 99%

The potential for vertical bone regeneration via maxillary periosteal elevation

Mouraret

Kaeppler

Bardet

et al. 2014

J Clinic Periodontology

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show abstract

“…Indeed, researchers have already integrated algorithms to predict optimal material layout in conjunction with mechanically adaptive tissue remodeling, 31,38 predicting, for instance, that optimal scaffold design targets that produce the most robust tissue formation may depend on porosity. 38 It is clear that despite significant strides in computational scaffold design over the past 10 years, there is still a long way to go. Hierarchical scaffold design that essentially breaks scaffold design down into distinct modules has been able to address significant realistic multiobjective problems in the past 5 years.…”

Section: Hierarchical Scaffold Designmentioning

confidence: 99%

Hierarchical bioactive materials for tissue reconstruction: Integrated design and manufacturing challenges

Hollister

2011

JOM

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“…Unfortunately, the mismatching of the mechanical properties of a material can bring about extra stress at the interface between the implants and the host tissue, limiting the ingrowth of cells and leading to inefficiency of tissue repair or regeneration [9]. Due to the discrepancy in the properties and regeneration conditions of different tissues, porous scaffolding biomaterials need varied mechanical properties and porous structures, which usually require vastly different fabrication strategies [10].…”

Section: Introductionmentioning

confidence: 99%

A versatile three-dimensional foam fabrication strategy for soft and hard tissue engineering

Bai

Yang

et al. 2018

Biomed. Mater.

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The fabrication strategies of three-dimensional porous biomaterials have been extensively studied and well established in the past few decades, yet the biocompatibility and versatility of porous architecture preparation is still lacking. Herewith, we present a novel and green 3D porous foam fabrication technique for both soft and hard engineering. By utilizing the gelatinization and retrogradation properties of starches, stabilized porous constructs made of various building blocks, from living cells to ceramic particles, were created for the first time. In soft tissue engineering applications, 3D cultured tissue foam (CTF) with controlled cell release properties was developed, and foams constituting osteoblasts, fibroblasts and vascular endothelial cells all exhibited high mechanical stability and preservation of cell viability or functions. More importantly, the CTF achieved sustained self-release of cells controlled by serum concentration (containing amylase) and the released cells also maintained high viability and functions. In the context of hard tissue engineering applications, ceramic/bioglass (BG) foam scaffolds were developed by a similar starch-assisted foaming strategy where the resultant bone scaffolds of hydroxyapatite (HA)/BG and Si 3 N 4 /BG possessed >70% porosity with interconnected macropores (sizes 200∼400 μm), fine pores (sizes 1∼10 μm) and superior mechanical properties despite the high porosity. Additionally, in vitro and in vivo evaluations of the biological properties revealed that porous HA/BG foam exhibits the desired biocompatibility and osteogenesis. The in vivo study indicated new bone ingrowth after 1 week and significant increases in new bone volume after 2 weeks. In conclusion, the presented foaming strategy provides opportunities for biofabricating CTF with different cells for different target soft tissues and preparing porous ceramic/ BG foams with different material components and high strengths, showing great versatility in soft and hard tissue engineering.

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On stiffness of scaffolds for bone tissue engineering—a numerical study

Cited by 92 publications

References 31 publications

The potential for vertical bone regeneration via maxillary periosteal elevation

The potential for vertical bone regeneration via maxillary periosteal elevation

Hierarchical bioactive materials for tissue reconstruction: Integrated design and manufacturing challenges

A versatile three-dimensional foam fabrication strategy for soft and hard tissue engineering

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