Infra-nilmanifolds are compact K(G, 1)-manifolds with G a torsion-free, finitely generated, virtually nilpotent group. Motivated by previous results of various authors on p-completions of K(G, 1)-spaces with G a finite or a nilpotent group, we study the homotopy type of p-completions of infra-nilmanifolds, for any prime p. We prove that the p-completion of an infra-nilmanifold is a virtually nilpotent space which is either aspherical or has infinitely many nonzero homotopy groups. The same is true for plocalization. Moreover, we show by means of examples that rationalizations of infra-nilmanifolds may be elliptic or hyperbolic.