Let K be a totally real number field and consider a Fermat‐type equation Aap+Bbq=Ccr$Aa^p+Bb^q=Cc^r$ over K. We call the triple of exponents false(p,q,rfalse)$(p,q,r)$ the signature of the equation. We prove various results concerning the solutions to the Fermat equation with signature false(p,p,2false)$(p,p,2)$ and false(p,p,3false)$(p,p,3)$ using a method involving modularity, level lowering and image of inertia comparison. These generalize and extend the recent work of Işik, Kara and Özman. For example, consider K a totally real field of degree n with 2∤hK+$2 \nmid h_K^+$ and 2 inert. Moreover, suppose there is a prime q⩾5$q\geqslant 5$ which totally ramifies in K and satisfies trueprefixgcdfalse(n,q−1false)=1$\gcd (n,q-1)=1$, then we know that the equation ap+bp=c2$a^p+b^p=c^2$ has no primitive, non‐trivial solutions (a,b,c)∈OK3$(a,b,c) \in \mathcal {O}_K^3$ with 2false|b$2 | b$ for p sufficiently large.