On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts

Disch, Andrea; Rohmer, Michel

doi:10.1111/j.1574-6968.1998.tb13274.x

Cited by 55 publications

(16 citation statements)

References 29 publications

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“…In this mechanism C1 forms a bond with C11 of the originating FPP molecule in the formation of a caryophyllenyl carbocation followed by opening of the cyclobutyl ring to yield the desired isobutenyl side chain. Important to note, the two methylene carbons of the isobutenyl side are predicted to arise from C1 and C11 of the originating FPP and hence should become labeled when [1][2][3][4][5][6][7][8][9][10][11][12][13] C]acetate is incorporated into FPP by the mevalonate biosynthetic pathway operating in yeast (32). This labeling pattern is indeed observed and consistent with the proposed caryophyllene reaction mechanism for valerena-1,10-diene synthase.…”

Section: Discussionsupporting

confidence: 61%

“…It is well characterized that [1-13 C]acetate can feed into the mevalonate pathway and become incorporated at positions 1 and 3 of the intermediate isopentenyl diphosphate (32). By following this biosynthetic logic, we envisage that feeding [1-13 C]acetate to VoTPS1-expressing yeast would result in the predicted incorporation of 13 C into the FPP substrate and the subsequent labeling of 2 at carbons 3, 5, 7, 9, 10, and 11 ( Fig.…”

Section: Structural Elucidation Of Sesquiterpene Products Frommentioning

confidence: 99%

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Functional Identification of Valerena-1,10-diene Synthase, a Terpene Synthase Catalyzing a Unique Chemical Cascade in the Biosynthesis of Biologically Active Sesquiterpenes in Valeriana officinalis

Yeo

Nybo

Chittiboyina

et al. 2013

Journal of Biological Chemistry

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Background: Therapeutic values of Valeriana officinalis have been associated with sesquiterpenes whose biosynthetic origins have remained enigmatic. Results: A cyclobutenyl intermediate in the catalytic cascade of valerena-1,10-diene synthase is reported. Conclusion: A new class of sesquiterpene synthases for the biosynthesis of sesquiterpenes harboring isobutenyl functional groups is proposed. Significance: Similar catalytic mechanisms from evolutionarily diverse organisms are proposed and portend sources for sesquiterpene diversity.

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Section: Discussionsupporting

confidence: 61%

Section: Structural Elucidation Of Sesquiterpene Products Frommentioning

confidence: 99%

Functional Identification of Valerena-1,10-diene Synthase, a Terpene Synthase Catalyzing a Unique Chemical Cascade in the Biosynthesis of Biologically Active Sesquiterpenes in Valeriana officinalis

Yeo

Nybo

Chittiboyina

et al. 2013

Journal of Biological Chemistry

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“…It has been shown, by biosynthetic labeling studies, that isoprenoids of the yeast Rhodotorula glutinis and of four fungal species are synthesized exclusively via the MVA pathway (23)(24)(25). A central enzyme of the MVA pathway, 3-hydroxy-3-methylglutaryl-CoA reductase, has been cloned and characterized from the fungus Gibberella fujikuroi (26).…”

Section: Resultsmentioning

confidence: 99%

Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes

Lange

Rujan²,

Martin³

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

744

529

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Isopentenyl diphosphate (IPP) is the central intermediate in the biosynthesis of isoprenoids, the most ancient and diverse class of natural products. Two distinct routes of IPP biosynthesis occur in nature: the mevalonate pathway and the recently discovered deoxyxylulose 5-phosphate (DXP) pathway. The evolutionary history of the enzymes involved in both routes and the phylogenetic distribution of their genes across genomes suggest that the mevalonate pathway is germane to archaebacteria, that the DXP pathway is germane to eubacteria, and that eukaryotes have inherited their genes for IPP biosynthesis from prokaryotes. The occurrence of genes specific to the DXP pathway is restricted to plastid-bearing eukaryotes, indicating that these genes were acquired from the cyanobacterial ancestor of plastids. However, the individual phylogenies of these genes, with only one exception, do not provide evidence for a specific affinity between the plant genes and their cyanobacterial homologues. The results suggest that lateral gene transfer between eubacteria subsequent to the origin of plastids has played a major role in the evolution of this pathway.chloroplast ͉ deoxyxylulose 5-phosphate ͉ endosymbiosis ͉ mevalonate ͉ phylogeny

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“…With the exception of plants, all other organisms such as bacteria [23], yeast [24] and animals [25] use only one of these pathways. Well studied in plants, thecytosolic mevalonicacid (MVA) pathway uses three molecules of acetyl CoA that are joined together stepwise to form mevalonic acid ( Figure 1(a)) [17].…”

Section: Biosynthesis and Distribution Of Vtcsmentioning

confidence: 99%

Plant Senescence: The Role of Volatile Terpene Compounds (VTCs)

Korankye¹,

Lada²,

Asiedu³

2017

AJPS

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Senescence is a natural, energy-dependent, physiological, developmental and an ecological process that is controlled by the plant's own genetic program, allowing maximum recovery of nutrients from older organs for the survival of the plant, as such; it is classified as essential component of the growth and development of plants. In some cases, under one or many environmental stresses, senescence is triggered in plants. Despite many studies in the area, less consideration has been given to plant secondary metabolites, especially the role of VTCs on plant senescence. This review seeks to capture the biosynthesis and signal transduction of VTCs, the physiology of VTCs in plant development and how that is linked to some phytohormones to induce senescence. Much progress has been made in the elucidation of metabolic pathways leading to the biosynthesis of VTCs. In addition to the classical cytosolic mevalonic acid (MVA) pathway from acetyl-CoA, the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, originating from glyceraldehyde-3-phosphate (GAP) and pyruvate, leads to the biosynthesis of isoprenoid precursors, isopentenyl diphosphate and dimethyl allyl diphosphate. VTCs synthesis and emission are believed to be tightly regulated by photosynthetic carbon supply into MEP pathway. Thus, under abiotic stresses such as drought, high salinity, high and low temperature, and low CO 2 that directly affect stomatal conductance and ultimately biochemical limitation to photosynthesis, there has been observed induction of VTC synthesis and emissions, reflecting the elicitation of MEP pathway. This reveals the possibility of important function(s) of VTCs in plant defense against stress by mobilizing resources from components of plants and therefore, senescence. Our current understanding of the relationship between environmental responses and senescence mostly comes from the study of senescence response to phytohormones such as abscisic acid, jasmonic acid, ethylene and salicylic acid, which are extensively involved in response to various abiotic and biotic stresses. These stresses affect synthesis and/or signaling pathways of phytohormones to eventually trigger expression of stress-responsive genes, which in turn appears to affect leaf senescence.Comparison of plant response to stresses in relation to patterns of VTCs and phytohormones biosynthesis indicates a considerable crosstalk between these metabolic processes and their signal to plant senescence.

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On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts

Cited by 55 publications

References 29 publications

Functional Identification of Valerena-1,10-diene Synthase, a Terpene Synthase Catalyzing a Unique Chemical Cascade in the Biosynthesis of Biologically Active Sesquiterpenes in Valeriana officinalis

Functional Identification of Valerena-1,10-diene Synthase, a Terpene Synthase Catalyzing a Unique Chemical Cascade in the Biosynthesis of Biologically Active Sesquiterpenes in Valeriana officinalis

Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes

Plant Senescence: The Role of Volatile Terpene Compounds (VTCs)

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