On the Accuracy of Hemolysis Models in Couette‐Type Blood Shearing Devices

Wu, Peng; Boehning, Fiete; Groß-Hardt, Sascha; Hsu, Po-Lin

doi:10.1111/aor.13292

Cited by 15 publications

(18 citation statements)

References 27 publications

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“…20–24 A common approach to consider turbulent effect on hemolysis is to formulate effective stress τeff using viscous stress together with Reynolds stress. 25–28 However, it has been shown that the Reynolds stress is an inaccurate indicator of turbulent effects on hemolysis, 29–33 and tends to overpredict the level of hemolysis. 24 Wu et al.…”

Section: Introductionmentioning

confidence: 99%

Effect of turbulent inlet conditions on the prediction of flow field and hemolysis in the FDA ideal medical device

Zhang

Gao

et al. 2019

Proceedings of the Institution of Mechanical Engineers, Part C:

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Hemolysis is one of the most important issues of blood contacting artificial organs. Computational fluid dynamics, in conjunction with hemolysis models, has been widely used to predict the flow field and hemolysis during the development phase of these devices. It is widely accepted that hemolysis is related to flow field parameters, such as stress and energy dissipation. It is known that inlet boundary conditions such as turbulent intensity have important effects on flow fields. Nonetheless, the influence of inlet turbulent intensity on hemolysis is not yet clear. This study investigates the influence of turbulent intensity on the prediction of flow field and hemolysis in the FDA benchmark nozzle model. Three configurations are investigated: first is the original nozzle model (with a gradual contraction, throat, and sudden expansion); the second is composed only of the throat and sudden expansion; the third one is similar with the second, but with a shorter throat. Four turbulent intensities are considered, ranging from 1% to 20%. For the first configuration, the influence of turbulent intensity on both flow field and hemolysis is very small and limited prior to the gradual contraction, while for the other two configurations, the influence is considerable. The jet breaks down sooner with increased turbulent intensity. Both turbulence dissipation rate and Reynolds stress increase in the throat with increased turbulent intensity, but decrease after the jet breaks down. The influence of turbulent intensity is more considerable for the configuration with a shorter inlet. The influence of turbulent intensity on the prediction of hemolysis is up to 38.5%. This study shows that turbulent intensity can have considerable influence on the prediction of flow field and hemolysis in blood-contacting devices, thus should be taken in account when conducting blood compatibility design.

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Section: Introductionmentioning

confidence: 99%

Effect of turbulent inlet conditions on the prediction of flow field and hemolysis in the FDA ideal medical device

Zhang

Gao

et al. 2019

Proceedings of the Institution of Mechanical Engineers, Part C:

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“…Goldsmith and Turitto 6 have determined these deviations in extensive comparative tests. Wu et al 26 were able to show that the critical limit of shear stresses determined with a frequently used Couette viscometer is only of limited significance for the occurrence of haemolysis. Beissinger and Laugel 27 were also able to demonstrate that the haemolysis level increases when the erythrocytes get into contact with foreign materials, regardless of the shear rate present.…”

Section: Resistance Of Erythrocytesmentioning

confidence: 99%

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Köhne

2020

Perfusion

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Since the use of continuous flow blood pumps as ventricular assist devices is standard, the problems with haemolysis have increased. It is mainly induced by shear stress affecting the erythrocyte membrane. There are many investigations about haemolysis in laminar and turbulent blood flow. The results defined as threshold levels for the damage of erythrocytes depend on the exposure time of the shear stress, but they are very different, depending on the used experimental methods or the calculation strategy. Here, the results are resumed and shown in curves. Different models for the calculation of the strengths of erythrocytes are discussed. There are few results reported about tests of haemolysis in blood pumps, but some theoretical approaches for the design of continuous flow blood pumps according to low haemolysis have been investigated within the last years.

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“…Peng Wu et al of Soochow University, Suzhou, Jiangsu, China, investigated the accuracy of hemolysis models in Couette‐type blood shearing devices. The study evaluated the influence of the nonuniform exposure time and rotor eccentricity or run‐out on the accuracy of power‐law hemolysis models, using both theoretical and CFD analysis.…”

Section: Bioengineering Biocompatibility and Biomaterialsmentioning

confidence: 99%

Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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In this Editor's Review, articles published in 2018 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed special issues this year included contributions from the 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, and the 25th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Marvin Slepian. Additionally, many editorials highlighted the worldwide survival differences in hemodialysis and perspectives on mechanical circulatory support and stem cell therapies for cardiac support. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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On the Accuracy of Hemolysis Models in Couette‐Type Blood Shearing Devices

Cited by 15 publications

References 27 publications

Effect of turbulent inlet conditions on the prediction of flow field and hemolysis in the FDA ideal medical device

Effect of turbulent inlet conditions on the prediction of flow field and hemolysis in the FDA ideal medical device

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Artificial Organs 2018: A Year in Review

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