On the Acidosis of Shock and Suspended Circulation.

Wright, Sheri

doi:10.1016/s0140-6736(01)27262-6

Cited by 7 publications

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“…On the Terra Nova expedition, Atkinson did regular blood tests to measure the alkalinity of the blood which was thought to be an indication of scurvy (Wright 1897, 1900) and he gives the results of two days’ investigations in his paper on the expedition (Atkinson 1915). The test itself was a valuable scientific advance and was used during World War I to measure the degree of metabolic acidosis in patients with shock (Wright and Colebrook 1918), but Almroth Wright's theory that scurvy was caused by acidosis was wrong and so the use of the test to detect scurvy was of no value. This is described elsewhere (Guly in press b).…”

Section: Tests For Scurvymentioning

confidence: 99%

Human biology investigations during the heroic age of Antarctic exploration (1897–1922)

Guly¹

2013

Polar Record

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This article describes the human biological data that was collected from the participants of the Antarctic expeditions of the ‘heroic age’ (1897–1922). Routine body weights, waist circumference, spirometry and grip strength measurements were performed on a number of the expeditions for monitoring health and at least four expeditions measured the haemoglobin level and demonstrated that anaemia did not occur. The only true research was done by Dr A.L. McLean of the Australasian Antarctic Expedition, who measured hair and nail growth and investigated immunity. By modern standards, the data collected is of little value but McLean's work laid the groundwork for modern research into the effects of Antarctic residence on the human organism.

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Section: Tests For Scurvymentioning

confidence: 99%

Human biology investigations during the heroic age of Antarctic exploration (1897–1922)

Guly¹

2013

Polar Record

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“…Hertzmann and Gesell (24) have noted that on suddenly restoring the blood volume after bleeding a temporary fall in the pH of the fluid may occur. The suggestion has been made (25,26) that local acidotic accumulations may suddenly be swept into the blood with result in harm to the organism. Our observation, that the ventilation of tissues which have become acidotic as the result of simple ischemia brings about a rapid reversion in them toward alkalinity, would seem to indicate that the relativelyinnocuous carbon dioxide plays a major r61e in determining local acidity under such circumstances.…”

Section: Distribution Of the Ischemlc Patchingmentioning

confidence: 99%

Outlying Acidosis Due to Functional Ischemia

Rous

Drury

1929

Journal of Experimental Medicine

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In various functional conditions involving peripheral vasoconstriction a more or less widespread change toward acidity takes place within certain tissues. The change is frequently independent of any in the blood. Indeed the blood can become more alkaline while the tissue acidosis is developing. When the blood volume is diminished abruptly but not too greatly, by hemorrhage or by anhydremia, the acidosis which develops in the superficial connective tissue and in the skeletal muscles is patchy in distribution, being limited to areas of local ischemia themselves the result of a compensatory vasoconstriction which affects certain regions only. There is a second type of patchy ischemia (and of acidosis) which occurs under circumstances of moderate depletion and is referable to local pressure differences that are so slight as to be ineffective under normal circumstances. A generalized acidosis throughout the superficial tissue develops when depletion is extreme. All these are outlying acidoses, since they lie without the influence of the blood. In the viscera no such acidoses have been found.

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Physical Injury and Its Effects on Protein Metabolism

Cuthbertson¹

1964

Mammalian Protein Metabolism

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On the Acidosis of Shock and Suspended Circulation.

Cited by 7 publications

References 0 publications

Human biology investigations during the heroic age of Antarctic exploration (1897–1922)

Human biology investigations during the heroic age of Antarctic exploration (1897–1922)

Outlying Acidosis Due to Functional Ischemia

Physical Injury and Its Effects on Protein Metabolism

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