We are interested in the quality of sound produced by musical instruments and their playability. In wind instruments, a hydrodynamic source of sound is coupled to an acoustic resonator. Linear acoustics can predict the pitch of an instrument. This can significantly reduce the trial-and-error process in the design of a new instrument. We consider deviations from the linear acoustic behavior and the fluid mechanics of the sound production. Realtime numerical solution of the nonlinear physical models is used for sound synthesis in so-called virtual instruments. Although reasonable analytical models are available for reeds, lips, and vocal folds, the complex behavior of flue instruments escapes a simple universal description. Furthermore, to predict the playability of real instruments and help phoneticians or surgeons analyze voice quality, we need more complex models.