The activation energy of creep rupture is determined based on a new tensile creep rupture model and then applied to rationalize the creep rupture data measured over a wide range of stresses and temperatures, which enabled the predictions of 100,000 hours and 200,000 hours creep rupture strengths to be made at different temperatures in the range of 650 °C to 875 °C for alloy Inconel 740/740H. The reliability of such long-term predictions is also analyzed.